Coronary artery calcium before and after hospitalization with pneumonia: The MESA study

Vicente F. Corrales-Medina, Girish Dwivedi, Monica Taljaard, William Petrcich, Joao Lima, Sachin Yende, Richard A. Kronmal, Julio A. Chirinos

Research output: Contribution to journalArticle

Abstract

Background Epidemiological analyses demonstrate that pneumonia survivors have a higher risk of myocardial infarction than people with similar load of risk factors for atherosclerotic cardiovascular disease (ASCVD) but without pneumonia. This may be due to a higher baseline burden of ASCVD in patients with pneumonia that is not captured by the accounting of known ASCVD risk factors in epidemiological analyses or to unfavorable accelerating effects of pneumonia on atherosclerosis. Methods We analyzed data from the Multi-Ethnic Study of Atherosclerosis. We identified 54 participants that were hospitalized for pneumonia during study follow-up and that also had assessment of coronary artery calcium (CAC, an objective marker of coronary atherosclerotic burden) before and after this hospitalization. We matched them to 54 participants who were not hospitalized for pneumonia but that had CAC assessments at the same study visits as the pneumonia cases. We compared baseline CAC scores and their progression between groups. Results Baseline CAC scores were similar in both groups (median [IQR]; 6.3 [0–356.8] in pneumonia participants vs. 10.8 [0–178.3] in controls; p = 0.25). After a median of 4.8 years, the direction and magnitude of CAC score change, and the slope of CAC score progression between groups was also similar (median change [IQR], 21.8 [0 to 287.29] in participants with pneumonia versus 15.8 [0 to 140.94] in controls, p = 0.28; difference in slope, 7.7, 95% CI -9.0 to 24.6, p = 0.18). However, among participants with high baseline ASCVD risk (i.e. ACC/AHA 10-year risk estimate 7.5%), participants with pneumonia showed a larger increase in CAC scores (median change [IQR]; 159.10 [38.55–407.34] versus 48.72 [0.97–246.99] in controls; p = 0.02) and a trend towards a steeper slope of CAC score progression (difference in slope, 19.7, 95% CI -6.6 to 45.6, p = 0.07). Conclusion Pneumonia may accelerate the progression of atherosclerosis in people with high baseline ASCVD risk.

Original languageEnglish (US)
Article numbere0191750
JournalPLoS One
Volume13
Issue number2
DOIs
StatePublished - Feb 1 2018

Fingerprint

coronary vessels
pneumonia
Pneumonia
Coronary Vessels
Hospitalization
Calcium
calcium
cardiovascular diseases
Cardiovascular Diseases
atherosclerosis
Atherosclerosis
risk factors
risk estimate
myocardial infarction
Survivors
Myocardial Infarction

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Corrales-Medina, V. F., Dwivedi, G., Taljaard, M., Petrcich, W., Lima, J., Yende, S., ... Chirinos, J. A. (2018). Coronary artery calcium before and after hospitalization with pneumonia: The MESA study. PLoS One, 13(2), [e0191750]. https://doi.org/10.1371/journal.pone.0191750

Coronary artery calcium before and after hospitalization with pneumonia : The MESA study. / Corrales-Medina, Vicente F.; Dwivedi, Girish; Taljaard, Monica; Petrcich, William; Lima, Joao; Yende, Sachin; Kronmal, Richard A.; Chirinos, Julio A.

In: PLoS One, Vol. 13, No. 2, e0191750, 01.02.2018.

Research output: Contribution to journalArticle

Corrales-Medina, VF, Dwivedi, G, Taljaard, M, Petrcich, W, Lima, J, Yende, S, Kronmal, RA & Chirinos, JA 2018, 'Coronary artery calcium before and after hospitalization with pneumonia: The MESA study', PLoS One, vol. 13, no. 2, e0191750. https://doi.org/10.1371/journal.pone.0191750
Corrales-Medina VF, Dwivedi G, Taljaard M, Petrcich W, Lima J, Yende S et al. Coronary artery calcium before and after hospitalization with pneumonia: The MESA study. PLoS One. 2018 Feb 1;13(2). e0191750. https://doi.org/10.1371/journal.pone.0191750
Corrales-Medina, Vicente F. ; Dwivedi, Girish ; Taljaard, Monica ; Petrcich, William ; Lima, Joao ; Yende, Sachin ; Kronmal, Richard A. ; Chirinos, Julio A. / Coronary artery calcium before and after hospitalization with pneumonia : The MESA study. In: PLoS One. 2018 ; Vol. 13, No. 2.
@article{06c1bcfd86034ef6940be6fa82a4ad8e,
title = "Coronary artery calcium before and after hospitalization with pneumonia: The MESA study",
abstract = "Background Epidemiological analyses demonstrate that pneumonia survivors have a higher risk of myocardial infarction than people with similar load of risk factors for atherosclerotic cardiovascular disease (ASCVD) but without pneumonia. This may be due to a higher baseline burden of ASCVD in patients with pneumonia that is not captured by the accounting of known ASCVD risk factors in epidemiological analyses or to unfavorable accelerating effects of pneumonia on atherosclerosis. Methods We analyzed data from the Multi-Ethnic Study of Atherosclerosis. We identified 54 participants that were hospitalized for pneumonia during study follow-up and that also had assessment of coronary artery calcium (CAC, an objective marker of coronary atherosclerotic burden) before and after this hospitalization. We matched them to 54 participants who were not hospitalized for pneumonia but that had CAC assessments at the same study visits as the pneumonia cases. We compared baseline CAC scores and their progression between groups. Results Baseline CAC scores were similar in both groups (median [IQR]; 6.3 [0–356.8] in pneumonia participants vs. 10.8 [0–178.3] in controls; p = 0.25). After a median of 4.8 years, the direction and magnitude of CAC score change, and the slope of CAC score progression between groups was also similar (median change [IQR], 21.8 [0 to 287.29] in participants with pneumonia versus 15.8 [0 to 140.94] in controls, p = 0.28; difference in slope, 7.7, 95{\%} CI -9.0 to 24.6, p = 0.18). However, among participants with high baseline ASCVD risk (i.e. ACC/AHA 10-year risk estimate 7.5{\%}), participants with pneumonia showed a larger increase in CAC scores (median change [IQR]; 159.10 [38.55–407.34] versus 48.72 [0.97–246.99] in controls; p = 0.02) and a trend towards a steeper slope of CAC score progression (difference in slope, 19.7, 95{\%} CI -6.6 to 45.6, p = 0.07). Conclusion Pneumonia may accelerate the progression of atherosclerosis in people with high baseline ASCVD risk.",
author = "Corrales-Medina, {Vicente F.} and Girish Dwivedi and Monica Taljaard and William Petrcich and Joao Lima and Sachin Yende and Kronmal, {Richard A.} and Chirinos, {Julio A.}",
year = "2018",
month = "2",
day = "1",
doi = "10.1371/journal.pone.0191750",
language = "English (US)",
volume = "13",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

TY - JOUR

T1 - Coronary artery calcium before and after hospitalization with pneumonia

T2 - The MESA study

AU - Corrales-Medina, Vicente F.

AU - Dwivedi, Girish

AU - Taljaard, Monica

AU - Petrcich, William

AU - Lima, Joao

AU - Yende, Sachin

AU - Kronmal, Richard A.

AU - Chirinos, Julio A.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Background Epidemiological analyses demonstrate that pneumonia survivors have a higher risk of myocardial infarction than people with similar load of risk factors for atherosclerotic cardiovascular disease (ASCVD) but without pneumonia. This may be due to a higher baseline burden of ASCVD in patients with pneumonia that is not captured by the accounting of known ASCVD risk factors in epidemiological analyses or to unfavorable accelerating effects of pneumonia on atherosclerosis. Methods We analyzed data from the Multi-Ethnic Study of Atherosclerosis. We identified 54 participants that were hospitalized for pneumonia during study follow-up and that also had assessment of coronary artery calcium (CAC, an objective marker of coronary atherosclerotic burden) before and after this hospitalization. We matched them to 54 participants who were not hospitalized for pneumonia but that had CAC assessments at the same study visits as the pneumonia cases. We compared baseline CAC scores and their progression between groups. Results Baseline CAC scores were similar in both groups (median [IQR]; 6.3 [0–356.8] in pneumonia participants vs. 10.8 [0–178.3] in controls; p = 0.25). After a median of 4.8 years, the direction and magnitude of CAC score change, and the slope of CAC score progression between groups was also similar (median change [IQR], 21.8 [0 to 287.29] in participants with pneumonia versus 15.8 [0 to 140.94] in controls, p = 0.28; difference in slope, 7.7, 95% CI -9.0 to 24.6, p = 0.18). However, among participants with high baseline ASCVD risk (i.e. ACC/AHA 10-year risk estimate 7.5%), participants with pneumonia showed a larger increase in CAC scores (median change [IQR]; 159.10 [38.55–407.34] versus 48.72 [0.97–246.99] in controls; p = 0.02) and a trend towards a steeper slope of CAC score progression (difference in slope, 19.7, 95% CI -6.6 to 45.6, p = 0.07). Conclusion Pneumonia may accelerate the progression of atherosclerosis in people with high baseline ASCVD risk.

AB - Background Epidemiological analyses demonstrate that pneumonia survivors have a higher risk of myocardial infarction than people with similar load of risk factors for atherosclerotic cardiovascular disease (ASCVD) but without pneumonia. This may be due to a higher baseline burden of ASCVD in patients with pneumonia that is not captured by the accounting of known ASCVD risk factors in epidemiological analyses or to unfavorable accelerating effects of pneumonia on atherosclerosis. Methods We analyzed data from the Multi-Ethnic Study of Atherosclerosis. We identified 54 participants that were hospitalized for pneumonia during study follow-up and that also had assessment of coronary artery calcium (CAC, an objective marker of coronary atherosclerotic burden) before and after this hospitalization. We matched them to 54 participants who were not hospitalized for pneumonia but that had CAC assessments at the same study visits as the pneumonia cases. We compared baseline CAC scores and their progression between groups. Results Baseline CAC scores were similar in both groups (median [IQR]; 6.3 [0–356.8] in pneumonia participants vs. 10.8 [0–178.3] in controls; p = 0.25). After a median of 4.8 years, the direction and magnitude of CAC score change, and the slope of CAC score progression between groups was also similar (median change [IQR], 21.8 [0 to 287.29] in participants with pneumonia versus 15.8 [0 to 140.94] in controls, p = 0.28; difference in slope, 7.7, 95% CI -9.0 to 24.6, p = 0.18). However, among participants with high baseline ASCVD risk (i.e. ACC/AHA 10-year risk estimate 7.5%), participants with pneumonia showed a larger increase in CAC scores (median change [IQR]; 159.10 [38.55–407.34] versus 48.72 [0.97–246.99] in controls; p = 0.02) and a trend towards a steeper slope of CAC score progression (difference in slope, 19.7, 95% CI -6.6 to 45.6, p = 0.07). Conclusion Pneumonia may accelerate the progression of atherosclerosis in people with high baseline ASCVD risk.

UR - http://www.scopus.com/inward/record.url?scp=85041962249&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041962249&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0191750

DO - 10.1371/journal.pone.0191750

M3 - Article

C2 - 29420547

AN - SCOPUS:85041962249

VL - 13

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 2

M1 - e0191750

ER -