Coronary artery calcification and family history of premature coronary heart disease: Sibling history is more strongly associated than parental history

Khurram Nasir, Erin Donnelly Michos, John A. Rumberger, Joel B. Braunstein, Wendy S Post, Matthew J. Budoff, Roger S Blumenthal

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Abstract

Background - The objective of the study was to assess the association of a family history (FH) of premature coronary heart disease (CHD) with coronary artery calcification (CAC) in asymptomatic individuals and to compare the effects of sibling or parental FH on the risk of subclinical atherosclerosis. Methods and Results - CAC by electron beam tomography was performed in 8549 asymptomatic individuals (69% men; mean age, 52±9 years). The prevalence and odds of any CAC and extent of CAC stratified according to FH of premature CHD were determined. Those with (1) no FH of CHD, (2) FH of premature CHD in parents, or (3) FH in siblings had a prevalence of CAC of 55%, 64%, and 78% (P

Original languageEnglish (US)
Pages (from-to)2150-2156
Number of pages7
JournalCirculation
Volume110
Issue number15
DOIs
Publication statusPublished - Oct 12 2004

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Keywords

  • Arteries
  • Atherosclerosis
  • Calcium
  • Tomography

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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