Coronary artery atherosclerosis is related to reduced regional left ventricular function in individuals without history of clinical cardiovascular disease: The multiethnic study of atherosclerosis

Thor Edvardsen, Robert Detrano, Boaz D. Rosen, J. Jeffrey Carr, Klang Liu, Shenghan Lai, Steven Shea, Li Pan, David A. Bluemke, Joao Lima

Research output: Contribution to journalArticle

Abstract

Objective - We investigated whether regional coronary calcium score by computed tomography is related to regional left ventricular systolic function measured by MRI tagging in participants of the Multiethnic Study of Atherosclerosis. Methods and Results - The Multiethnic Study of Atherosclerosis is a prospective observational study of men and women without a history of previous heart disease from 4 ethnic groups. Calcium scores were measured separately for the left anterior descendent (LAD), left circumflex (LCX), and right (RCA) coronary arteries. Left ventricular strain and strain rate were determined by tagged MRI in the corresponding vascular territories of the coronary vessels in 509 participants. Greater coronary calcification in the LAD, LCX, and right RCA coronary arteries were related to worse function in their respective perfusion. Anterior wall strain rate was -1.37±0.41 when LAD calcium was zero versus -1.17±0.24 1/s in the highest quartile of calcium score (P

Original languageEnglish (US)
Pages (from-to)206-211
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume26
Issue number1
DOIs
StatePublished - Jan 2006

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Left Ventricular Function
Coronary Artery Disease
Atherosclerosis
Coronary Vessels
Cardiovascular Diseases
Calcium
Ethnic Groups
Observational Studies
Blood Vessels
Heart Diseases
Perfusion
Tomography
Prospective Studies

Keywords

  • Atherosclerosis
  • Calcification
  • Coronary circulation
  • MRI
  • Myocardial function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Coronary artery atherosclerosis is related to reduced regional left ventricular function in individuals without history of clinical cardiovascular disease : The multiethnic study of atherosclerosis. / Edvardsen, Thor; Detrano, Robert; Rosen, Boaz D.; Carr, J. Jeffrey; Liu, Klang; Lai, Shenghan; Shea, Steven; Pan, Li; Bluemke, David A.; Lima, Joao.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 26, No. 1, 01.2006, p. 206-211.

Research output: Contribution to journalArticle

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