Corneoscleral xanthogranuloma treated with chemotherapy

The room for nonsurgical management

Osama M. Mustafa, Yassine Daoud

Research output: Contribution to journalArticle

Abstract

Purpose: To describe a clinical case of corneoscleral xanthogranuloma, a rare manifestation of juvenile xanthogranuloma, and xanthoma disseminatum, which responded well to chemotherapy. Methods: Interventional case report and literature search. Results: A 9-year-old female patient with a disseminated disease showed complete regression of her corneoscleral xanthogranuloma with methotrexate and azathioprine therapy. Conclusion: Since they are potentially blinding, corneoscleral xanthogranulomas are commonly surgically excised. While surgical resection has been widely advocated in the literature, immunosuppressive therapy alone may be a pertinent management line of corneoscleral xanthogranuloma, especially with systemic involvement.

Original languageEnglish (US)
JournalEuropean journal of ophthalmology
DOIs
StatePublished - Jan 1 2019

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Juvenile Xanthogranuloma
Non-Langerhans-Cell Histiocytosis
Drug Therapy
Azathioprine
Immunosuppressive Agents
Methotrexate
Therapeutics

Keywords

  • Azathioprine
  • corneoscleral
  • juvenile xanthogranuloma
  • limbal
  • methotrexate
  • xanthoma disseminatum

ASJC Scopus subject areas

  • Ophthalmology

Cite this

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abstract = "Purpose: To describe a clinical case of corneoscleral xanthogranuloma, a rare manifestation of juvenile xanthogranuloma, and xanthoma disseminatum, which responded well to chemotherapy. Methods: Interventional case report and literature search. Results: A 9-year-old female patient with a disseminated disease showed complete regression of her corneoscleral xanthogranuloma with methotrexate and azathioprine therapy. Conclusion: Since they are potentially blinding, corneoscleral xanthogranulomas are commonly surgically excised. While surgical resection has been widely advocated in the literature, immunosuppressive therapy alone may be a pertinent management line of corneoscleral xanthogranuloma, especially with systemic involvement.",
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AB - Purpose: To describe a clinical case of corneoscleral xanthogranuloma, a rare manifestation of juvenile xanthogranuloma, and xanthoma disseminatum, which responded well to chemotherapy. Methods: Interventional case report and literature search. Results: A 9-year-old female patient with a disseminated disease showed complete regression of her corneoscleral xanthogranuloma with methotrexate and azathioprine therapy. Conclusion: Since they are potentially blinding, corneoscleral xanthogranulomas are commonly surgically excised. While surgical resection has been widely advocated in the literature, immunosuppressive therapy alone may be a pertinent management line of corneoscleral xanthogranuloma, especially with systemic involvement.

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KW - limbal

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