Abstract
Purpose: To describe a clinical case of corneoscleral xanthogranuloma, a rare manifestation of juvenile xanthogranuloma, and xanthoma disseminatum, which responded well to chemotherapy. Methods: Interventional case report and literature search. Results: A 9-year-old female patient with a disseminated disease showed complete regression of her corneoscleral xanthogranuloma with methotrexate and azathioprine therapy. Conclusion: Since they are potentially blinding, corneoscleral xanthogranulomas are commonly surgically excised. While surgical resection has been widely advocated in the literature, immunosuppressive therapy alone may be a pertinent management line of corneoscleral xanthogranuloma, especially with systemic involvement.
| Original language | English (US) |
|---|---|
| Journal | European journal of ophthalmology |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- Azathioprine
- corneoscleral
- juvenile xanthogranuloma
- limbal
- methotrexate
- xanthoma disseminatum
ASJC Scopus subject areas
- Ophthalmology
Cite this
Corneoscleral xanthogranuloma treated with chemotherapy : The room for nonsurgical management. / Mustafa, Osama M.; Daoud, Yassine.
In: European journal of ophthalmology, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Corneoscleral xanthogranuloma treated with chemotherapy
T2 - The room for nonsurgical management
AU - Mustafa, Osama M.
AU - Daoud, Yassine
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Purpose: To describe a clinical case of corneoscleral xanthogranuloma, a rare manifestation of juvenile xanthogranuloma, and xanthoma disseminatum, which responded well to chemotherapy. Methods: Interventional case report and literature search. Results: A 9-year-old female patient with a disseminated disease showed complete regression of her corneoscleral xanthogranuloma with methotrexate and azathioprine therapy. Conclusion: Since they are potentially blinding, corneoscleral xanthogranulomas are commonly surgically excised. While surgical resection has been widely advocated in the literature, immunosuppressive therapy alone may be a pertinent management line of corneoscleral xanthogranuloma, especially with systemic involvement.
AB - Purpose: To describe a clinical case of corneoscleral xanthogranuloma, a rare manifestation of juvenile xanthogranuloma, and xanthoma disseminatum, which responded well to chemotherapy. Methods: Interventional case report and literature search. Results: A 9-year-old female patient with a disseminated disease showed complete regression of her corneoscleral xanthogranuloma with methotrexate and azathioprine therapy. Conclusion: Since they are potentially blinding, corneoscleral xanthogranulomas are commonly surgically excised. While surgical resection has been widely advocated in the literature, immunosuppressive therapy alone may be a pertinent management line of corneoscleral xanthogranuloma, especially with systemic involvement.
KW - Azathioprine
KW - corneoscleral
KW - juvenile xanthogranuloma
KW - limbal
KW - methotrexate
KW - xanthoma disseminatum
UR - http://www.scopus.com/inward/record.url?scp=85062457977&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85062457977&partnerID=8YFLogxK
U2 - 10.1177/1120672119832187
DO - 10.1177/1120672119832187
M3 - Article
C2 - 30813780
AN - SCOPUS:85062457977
JO - European Journal of Ophthalmology
JF - European Journal of Ophthalmology
SN - 1120-6721
ER -