Corneal wound healing after excimer laser ablation: Effects of nitrogen gas blower

M. Campos, K. Cuevas, J. Garbus, M. Lee, Peter J McDonnell

Research output: Contribution to journalArticle

Abstract

Purpose: To examine the effects of blowing nitrogen gas over the cornea during photorefractive keratectomy. Methods: Excimer laser ablations for myopia were performed on rabbit corneas with or without the blowing of nitrogen across the surface of the cornea. All eyes underwent a 5-diopter myopic ablation; in 8 eyes, a ring was used to blow nitrogen gas across the cornea, and, in 8 eyes, the same ring was used, but no nitrogen gas was blown. Results: Epithelial healing occurred more rapidly in the eyes that were not treated with the gas (3.8 ± 1.3 days) than in the gas-treated group (6.1 ± 0.8 days; P = 0.0025). Corneal haze was greater in the group treated with gas. Results of histologic examination showed the ablated area to have a smoother surface when nitrogen was not blown across the cornea surface. Conclusion: Superficial corneal deturgescence produced by the nitrogen gas appears to result in a rougher surface immediately postoperatively with undesirable effects on surface healing, but further studies will be necessary to determine the applicability of these results to humans.

Original languageEnglish (US)
Pages (from-to)893-897
Number of pages5
JournalOphthalmology
Volume99
Issue number6
StatePublished - 1992
Externally publishedYes

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Excimer Lasers
Laser Therapy
Wound Healing
Nitrogen
Gases
Cornea
Photorefractive Keratectomy
Myopia
Rabbits

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Corneal wound healing after excimer laser ablation : Effects of nitrogen gas blower. / Campos, M.; Cuevas, K.; Garbus, J.; Lee, M.; McDonnell, Peter J.

In: Ophthalmology, Vol. 99, No. 6, 1992, p. 893-897.

Research output: Contribution to journalArticle

Campos, M, Cuevas, K, Garbus, J, Lee, M & McDonnell, PJ 1992, 'Corneal wound healing after excimer laser ablation: Effects of nitrogen gas blower', Ophthalmology, vol. 99, no. 6, pp. 893-897.
Campos, M. ; Cuevas, K. ; Garbus, J. ; Lee, M. ; McDonnell, Peter J. / Corneal wound healing after excimer laser ablation : Effects of nitrogen gas blower. In: Ophthalmology. 1992 ; Vol. 99, No. 6. pp. 893-897.
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