Corneal sensitivity and burning sensation: Comparing topical ketorolac and diclofenac

Berthold Seitz, Kris Sorken, Laurie D. LaBree, Jenny J. Garbus, Peter J McDonnell

Research output: Contribution to journalArticle

Abstract

Objectives: To compare the effect of topical 0.5% ketorolac tromethamine and 0.1% diclofenac sodium on human corneal sensitivity and to assess the intensity of burning sensation at specific intervals after drop instillation. Design and Setting: Double-masked parallel clinical study. Patients: Eleven women and 4 men (8 white, 4 Hispanic, 3 Asian), 22 to 60 years of age (mean[±SD], 34±10 years). Interventions: Repeated instillation of either ketorolac and placebo or diclofenac and placebo at 5- minute intervals. Main Outcome Measures: Assessment of corneal sensitivity before instillation, immediately after instillation, and after termination of drop application; and subjective evaluation of burning sensation by asking participants to rate burning on a scale ranging from 0 (none) to 3 (severe) after each drop application. Results: Both diclofenac (P

Original languageEnglish (US)
Pages (from-to)921-924
Number of pages4
JournalArchives of Ophthalmology
Volume114
Issue number8
StatePublished - Aug 1996
Externally publishedYes

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Ketorolac
Diclofenac
Ketorolac Tromethamine
Placebos
Outcome Assessment (Health Care)
Hispanic Americans

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Corneal sensitivity and burning sensation : Comparing topical ketorolac and diclofenac. / Seitz, Berthold; Sorken, Kris; LaBree, Laurie D.; Garbus, Jenny J.; McDonnell, Peter J.

In: Archives of Ophthalmology, Vol. 114, No. 8, 08.1996, p. 921-924.

Research output: Contribution to journalArticle

Seitz, B, Sorken, K, LaBree, LD, Garbus, JJ & McDonnell, PJ 1996, 'Corneal sensitivity and burning sensation: Comparing topical ketorolac and diclofenac', Archives of Ophthalmology, vol. 114, no. 8, pp. 921-924.
Seitz, Berthold ; Sorken, Kris ; LaBree, Laurie D. ; Garbus, Jenny J. ; McDonnell, Peter J. / Corneal sensitivity and burning sensation : Comparing topical ketorolac and diclofenac. In: Archives of Ophthalmology. 1996 ; Vol. 114, No. 8. pp. 921-924.
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