Corneal endothelial injury thresholds for exposures to 1.54 μm radiation

Russell L. McCally, Jennifer Bonney-Ray, Zenaida De La Cruz, W. Richard Green

Research output: Contribution to journalArticle

Abstract

The endothelial injury threshold was determined in rabbit for an 11-s exposure to 1.54 μm radiation from an Erbium fiber laser. The beam was Gaussian with a 1/e diameter of 7 mm. Cell damage was detected with a wet staining technique. The threshold dose for these conditions is 4.4 × 10 J m (44 J cm) and is only 9% greater than the threshold for epithelial damage for the same exposure conditions. Exposures just above the threshold caused substantial endothelial damage, including loss of cells. The calculated endothelial temperature increase at the threshold is similar to that calculated for the epithelium at its injury threshold for the same exposure conditions. The results suggest that endothelial damage can be correlated with a critical temperature damage model with a critical temperature increase near 40°C. The results also suggest that if a person were to receive an exposure only slightly above the epithelial injury threshold from a beam having a diameter of 7 mm (which is the diameter of the exit pupil of 7 × 50 binoculars) he or she would risk sustaining substantial endothelial damage.

Original languageEnglish (US)
Pages (from-to)205-211
Number of pages7
JournalHealth Physics
Volume92
Issue number3
DOIs
StatePublished - Mar 2007

Fingerprint

Radiation
Temperature
thresholds
damage
Wounds and Injuries
radiation
Erbium
Telescopes
Binoculars
Gaussian beams
Pupil
Fiber lasers
Lasers
Epithelium
Cells
critical temperature
Staining and Labeling
Rabbits
epithelium
sustaining

Keywords

  • Health effects
  • Lasers
  • Modeling, biological factors
  • Safety standards

ASJC Scopus subject areas

  • Environmental Science (miscellaneous)
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Physics and Astronomy (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Environmental Chemistry
  • Environmental Science(all)

Cite this

McCally, R. L., Bonney-Ray, J., De La Cruz, Z., & Green, W. R. (2007). Corneal endothelial injury thresholds for exposures to 1.54 μm radiation. Health Physics, 92(3), 205-211. https://doi.org/10.1097/01.HP.0000248146.90949.0d

Corneal endothelial injury thresholds for exposures to 1.54 μm radiation. / McCally, Russell L.; Bonney-Ray, Jennifer; De La Cruz, Zenaida; Green, W. Richard.

In: Health Physics, Vol. 92, No. 3, 03.2007, p. 205-211.

Research output: Contribution to journalArticle

McCally, RL, Bonney-Ray, J, De La Cruz, Z & Green, WR 2007, 'Corneal endothelial injury thresholds for exposures to 1.54 μm radiation', Health Physics, vol. 92, no. 3, pp. 205-211. https://doi.org/10.1097/01.HP.0000248146.90949.0d
McCally, Russell L. ; Bonney-Ray, Jennifer ; De La Cruz, Zenaida ; Green, W. Richard. / Corneal endothelial injury thresholds for exposures to 1.54 μm radiation. In: Health Physics. 2007 ; Vol. 92, No. 3. pp. 205-211.
@article{fa9a6ea252d64d5f9eb532ed32d963e5,
title = "Corneal endothelial injury thresholds for exposures to 1.54 μm radiation",
abstract = "The endothelial injury threshold was determined in rabbit for an 11-s exposure to 1.54 μm radiation from an Erbium fiber laser. The beam was Gaussian with a 1/e diameter of 7 mm. Cell damage was detected with a wet staining technique. The threshold dose for these conditions is 4.4 × 10 J m (44 J cm) and is only 9{\%} greater than the threshold for epithelial damage for the same exposure conditions. Exposures just above the threshold caused substantial endothelial damage, including loss of cells. The calculated endothelial temperature increase at the threshold is similar to that calculated for the epithelium at its injury threshold for the same exposure conditions. The results suggest that endothelial damage can be correlated with a critical temperature damage model with a critical temperature increase near 40°C. The results also suggest that if a person were to receive an exposure only slightly above the epithelial injury threshold from a beam having a diameter of 7 mm (which is the diameter of the exit pupil of 7 × 50 binoculars) he or she would risk sustaining substantial endothelial damage.",
keywords = "Health effects, Lasers, Modeling, biological factors, Safety standards",
author = "McCally, {Russell L.} and Jennifer Bonney-Ray and {De La Cruz}, Zenaida and Green, {W. Richard}",
year = "2007",
month = "3",
doi = "10.1097/01.HP.0000248146.90949.0d",
language = "English (US)",
volume = "92",
pages = "205--211",
journal = "Health Physics",
issn = "0017-9078",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Corneal endothelial injury thresholds for exposures to 1.54 μm radiation

AU - McCally, Russell L.

AU - Bonney-Ray, Jennifer

AU - De La Cruz, Zenaida

AU - Green, W. Richard

PY - 2007/3

Y1 - 2007/3

N2 - The endothelial injury threshold was determined in rabbit for an 11-s exposure to 1.54 μm radiation from an Erbium fiber laser. The beam was Gaussian with a 1/e diameter of 7 mm. Cell damage was detected with a wet staining technique. The threshold dose for these conditions is 4.4 × 10 J m (44 J cm) and is only 9% greater than the threshold for epithelial damage for the same exposure conditions. Exposures just above the threshold caused substantial endothelial damage, including loss of cells. The calculated endothelial temperature increase at the threshold is similar to that calculated for the epithelium at its injury threshold for the same exposure conditions. The results suggest that endothelial damage can be correlated with a critical temperature damage model with a critical temperature increase near 40°C. The results also suggest that if a person were to receive an exposure only slightly above the epithelial injury threshold from a beam having a diameter of 7 mm (which is the diameter of the exit pupil of 7 × 50 binoculars) he or she would risk sustaining substantial endothelial damage.

AB - The endothelial injury threshold was determined in rabbit for an 11-s exposure to 1.54 μm radiation from an Erbium fiber laser. The beam was Gaussian with a 1/e diameter of 7 mm. Cell damage was detected with a wet staining technique. The threshold dose for these conditions is 4.4 × 10 J m (44 J cm) and is only 9% greater than the threshold for epithelial damage for the same exposure conditions. Exposures just above the threshold caused substantial endothelial damage, including loss of cells. The calculated endothelial temperature increase at the threshold is similar to that calculated for the epithelium at its injury threshold for the same exposure conditions. The results suggest that endothelial damage can be correlated with a critical temperature damage model with a critical temperature increase near 40°C. The results also suggest that if a person were to receive an exposure only slightly above the epithelial injury threshold from a beam having a diameter of 7 mm (which is the diameter of the exit pupil of 7 × 50 binoculars) he or she would risk sustaining substantial endothelial damage.

KW - Health effects

KW - Lasers

KW - Modeling, biological factors

KW - Safety standards

UR - http://www.scopus.com/inward/record.url?scp=33846970545&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846970545&partnerID=8YFLogxK

U2 - 10.1097/01.HP.0000248146.90949.0d

DO - 10.1097/01.HP.0000248146.90949.0d

M3 - Article

C2 - 17293691

AN - SCOPUS:33846970545

VL - 92

SP - 205

EP - 211

JO - Health Physics

JF - Health Physics

SN - 0017-9078

IS - 3

ER -