Corneal decompensation in mitochondrial ophthalmoplegia plus (Kearns- Sayre) syndrome: A clinicopathologic case report

T. S. Chang; D. R. Johns; W. J. Stark; D. B. Drachman; W. R. Green

doi:10.1097/00003226-199405000-00014

Corneal decompensation in mitochondrial ophthalmoplegia plus (Kearns- Sayre) syndrome: A clinicopathologic case report

T. S. Chang, D. R. Johns, W. J. Stark, D. B. Drachman, W. R. Green

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The authors describe the clinical, molecular genetic, and pathologic findings of a patient with corneal decompensation associated with the mitochondrial ophthalmoplegia plus (Kearns-Sayre) syndrome. Ultrastructurally abnormal mitochondria were observed and possibly implicate this organelle in the pathogenesis of corneal edema.

Original language	English (US)
Pages (from-to)	269-273
Number of pages	5
Journal	Cornea
Volume	13
Issue number	3
DOIs	https://doi.org/10.1097/00003226-199405000-00014
State	Published - 1994
Externally published	Yes

Keywords

Clinicopathologic correlation
Corneal decompensation
Electron microscopy
Kearns-Sayre syndrome
Mitochondria
Mitochondrial encephalomyopathy
Ophthalmoplegia plus
Progressive external ophthalmoplegia

ASJC Scopus subject areas

Ophthalmology

Access to Document

10.1097/00003226-199405000-00014

Cite this

@article{77f6a9103a174783874c4bc00111228a,

title = "Corneal decompensation in mitochondrial ophthalmoplegia plus (Kearns- Sayre) syndrome: A clinicopathologic case report",

abstract = "The authors describe the clinical, molecular genetic, and pathologic findings of a patient with corneal decompensation associated with the mitochondrial ophthalmoplegia plus (Kearns-Sayre) syndrome. Ultrastructurally abnormal mitochondria were observed and possibly implicate this organelle in the pathogenesis of corneal edema.",

keywords = "Clinicopathologic correlation, Corneal decompensation, Electron microscopy, Kearns-Sayre syndrome, Mitochondria, Mitochondrial encephalomyopathy, Ophthalmoplegia plus, Progressive external ophthalmoplegia",

author = "Chang, {T. S.} and Johns, {D. R.} and Stark, {W. J.} and Drachman, {D. B.} and Green, {W. R.}",

year = "1994",

doi = "10.1097/00003226-199405000-00014",

language = "English (US)",

volume = "13",

pages = "269--273",

journal = "Cornea",

issn = "0277-3740",

publisher = "Lippincott Williams and Wilkins",

number = "3",

}

TY - JOUR

T1 - Corneal decompensation in mitochondrial ophthalmoplegia plus (Kearns- Sayre) syndrome

T2 - A clinicopathologic case report

AU - Chang, T. S.

AU - Johns, D. R.

AU - Stark, W. J.

AU - Drachman, D. B.

AU - Green, W. R.

PY - 1994

Y1 - 1994

N2 - The authors describe the clinical, molecular genetic, and pathologic findings of a patient with corneal decompensation associated with the mitochondrial ophthalmoplegia plus (Kearns-Sayre) syndrome. Ultrastructurally abnormal mitochondria were observed and possibly implicate this organelle in the pathogenesis of corneal edema.

AB - The authors describe the clinical, molecular genetic, and pathologic findings of a patient with corneal decompensation associated with the mitochondrial ophthalmoplegia plus (Kearns-Sayre) syndrome. Ultrastructurally abnormal mitochondria were observed and possibly implicate this organelle in the pathogenesis of corneal edema.

KW - Clinicopathologic correlation

KW - Corneal decompensation

KW - Electron microscopy

KW - Kearns-Sayre syndrome

KW - Mitochondria

KW - Mitochondrial encephalomyopathy

KW - Ophthalmoplegia plus

KW - Progressive external ophthalmoplegia

UR - http://www.scopus.com/inward/record.url?scp=0028224462&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028224462&partnerID=8YFLogxK

U2 - 10.1097/00003226-199405000-00014

DO - 10.1097/00003226-199405000-00014

M3 - Article

C2 - 8033580

AN - SCOPUS:0028224462

SN - 0277-3740

VL - 13

SP - 269

EP - 273

JO - Cornea

JF - Cornea

IS - 3

ER -

Corneal decompensation in mitochondrial ophthalmoplegia plus (Kearns- Sayre) syndrome: A clinicopathologic case report

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this