Core-Shell Hydrogel Microcapsules for Improved Islets Encapsulation

Minglin Ma; Alan Chiu; Gaurav Sahay; Joshua C. Doloff; Nimit Dholakia; Raj Thakrar; Joshua Cohen; Arturo Vegas; Delai Chen; Kaitlin M. Bratlie; Tram Dang; Roger L. York; Jennifer Hollister-Lock; Gordon C. Weir; Daniel G. Anderson

doi:10.1002/adhm.201200341

Core-Shell Hydrogel Microcapsules for Improved Islets Encapsulation

Minglin Ma, Alan Chiu, Gaurav Sahay, Joshua C. Doloff, Nimit Dholakia, Raj Thakrar, Joshua Cohen, Arturo Vegas, Delai Chen, Kaitlin M. Bratlie, Tram Dang, Roger L. York, Jennifer Hollister-Lock, Gordon C. Weir, Daniel G. Anderson

School of Medicine

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

Islets microencapsulation holds great promise to treat type 1 diabetes. Currently used alginate microcapsules often have islets protruding outside capsules, leading to inadequate immuno-protection. A novel design of microcapsules with core-shell structures using a two-fluid co-axial electro-jetting is reported. Improved encapsulation and diabetes correction is achieved in a single step by simply confining the islets in the core region of the capsules.

Original language	English (US)
Pages (from-to)	667-672
Number of pages	6
Journal	Advanced Healthcare Materials
Volume	2
Issue number	5
DOIs	https://doi.org/10.1002/adhm.201200341
State	Published - May 2013

Keywords

Core-shell structures
Hydrogels
Immuno-protection
Islets encapsulation
Microcapsules
Transplantation

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering
Pharmaceutical Science

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10.1002/adhm.201200341

Cite this

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title = "Core-Shell Hydrogel Microcapsules for Improved Islets Encapsulation",

abstract = "Islets microencapsulation holds great promise to treat type 1 diabetes. Currently used alginate microcapsules often have islets protruding outside capsules, leading to inadequate immuno-protection. A novel design of microcapsules with core-shell structures using a two-fluid co-axial electro-jetting is reported. Improved encapsulation and diabetes correction is achieved in a single step by simply confining the islets in the core region of the capsules.",

keywords = "Core-shell structures, Hydrogels, Immuno-protection, Islets encapsulation, Microcapsules, Transplantation",

author = "Minglin Ma and Alan Chiu and Gaurav Sahay and Doloff, {Joshua C.} and Nimit Dholakia and Raj Thakrar and Joshua Cohen and Arturo Vegas and Delai Chen and Bratlie, {Kaitlin M.} and Tram Dang and York, {Roger L.} and Jennifer Hollister-Lock and Weir, {Gordon C.} and Anderson, {Daniel G.}",

year = "2013",

month = may,

doi = "10.1002/adhm.201200341",

language = "English (US)",

volume = "2",

pages = "667--672",

journal = "Advanced Healthcare Materials",

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T1 - Core-Shell Hydrogel Microcapsules for Improved Islets Encapsulation

AU - Ma, Minglin

AU - Chiu, Alan

AU - Sahay, Gaurav

AU - Doloff, Joshua C.

AU - Dholakia, Nimit

AU - Thakrar, Raj

AU - Cohen, Joshua

AU - Vegas, Arturo

AU - Chen, Delai

AU - Bratlie, Kaitlin M.

AU - Dang, Tram

AU - York, Roger L.

AU - Hollister-Lock, Jennifer

AU - Weir, Gordon C.

AU - Anderson, Daniel G.

PY - 2013/5

Y1 - 2013/5

N2 - Islets microencapsulation holds great promise to treat type 1 diabetes. Currently used alginate microcapsules often have islets protruding outside capsules, leading to inadequate immuno-protection. A novel design of microcapsules with core-shell structures using a two-fluid co-axial electro-jetting is reported. Improved encapsulation and diabetes correction is achieved in a single step by simply confining the islets in the core region of the capsules.

AB - Islets microencapsulation holds great promise to treat type 1 diabetes. Currently used alginate microcapsules often have islets protruding outside capsules, leading to inadequate immuno-protection. A novel design of microcapsules with core-shell structures using a two-fluid co-axial electro-jetting is reported. Improved encapsulation and diabetes correction is achieved in a single step by simply confining the islets in the core region of the capsules.

KW - Core-shell structures

KW - Hydrogels

KW - Immuno-protection

KW - Islets encapsulation

KW - Microcapsules

KW - Transplantation

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Core-Shell Hydrogel Microcapsules for Improved Islets Encapsulation

Abstract

Keywords

ASJC Scopus subject areas

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