TY - JOUR
T1 - Core outcomes sets for studies evaluating critical illness and patient recovery
AU - Dinglas, Victor D.
AU - Cherukuri, Sai P.S.
AU - Needham, Dale M.
N1 - Funding Information:
The current work received funding from the National Institutes of Health/National Heart, Lung, and Blood Institute (R24HL111895).
Funding Information:
Additional resources are available through the US National Institutes of Health (NIH)/NHLBI funded the Improving Long-Term Outcomes Research for Acute Respiratory Failure project (grant R24HL111895, www.improvelto.com) that include a rigorous international COS/COMS project. This critical care project has customizable COS/COMS templates to assist others who are designing and conducting COS/COMS (www.improvelto.com/ cos-resources/), including E-Mail templates (e.g., invitation to participate, notice of Delphi round commencement, reminders) and a template for standardized presentation of information for each outcome measure being considered for the COMS. The latter has been successfully adopted by the NIH/ National Institute on Aging-funded NIDUS project that has created infrastructure for delirium research (https://deliriumnetwork.org/measurement/).
Publisher Copyright:
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2020/10
Y1 - 2020/10
N2 - Purpose of review Given the growing body of critical care clinical research publications, core outcome sets (COSs) are important to help mitigate heterogeneity in outcomes assessed and measurement instruments used, and have potential to reduce research waste. This article provides an update on COS projects in critical care medicine, and related resources and tools for COS developers. Recent findings We identified 28 unique COS projects, of which 15 have published results as of May 2020. COS topics relevant to critical care medicine include mechanical ventilation, cardiology, stroke, rehabilitation, and long-term outcomes (LTOs) after critical illness. There are four COS projects for coronavirus disease 2019 (COVID-19), with a 'meta-COS' summarizing common outcomes across these projects. To help facilitate COS development, there are existing resources, standards, guidelines, and tools available from the Core Outcome Measures in Effectiveness Trials Initiative (www.comet-initiative.org/) and the National Institutes of Health-funded Improve LTO project (www.improvelto.com/). Summary Many COS projects have been completed in critical care, with more on-going COS projects, including foci from across the spectrum of acute critical care, COVID-19, critical care rehabilitation, and patient recovery and LTOs. Extensive resources are accessible to help facilitate rigorous COS development.
AB - Purpose of review Given the growing body of critical care clinical research publications, core outcome sets (COSs) are important to help mitigate heterogeneity in outcomes assessed and measurement instruments used, and have potential to reduce research waste. This article provides an update on COS projects in critical care medicine, and related resources and tools for COS developers. Recent findings We identified 28 unique COS projects, of which 15 have published results as of May 2020. COS topics relevant to critical care medicine include mechanical ventilation, cardiology, stroke, rehabilitation, and long-term outcomes (LTOs) after critical illness. There are four COS projects for coronavirus disease 2019 (COVID-19), with a 'meta-COS' summarizing common outcomes across these projects. To help facilitate COS development, there are existing resources, standards, guidelines, and tools available from the Core Outcome Measures in Effectiveness Trials Initiative (www.comet-initiative.org/) and the National Institutes of Health-funded Improve LTO project (www.improvelto.com/). Summary Many COS projects have been completed in critical care, with more on-going COS projects, including foci from across the spectrum of acute critical care, COVID-19, critical care rehabilitation, and patient recovery and LTOs. Extensive resources are accessible to help facilitate rigorous COS development.
KW - Consensus
KW - Core outcome set
KW - Coronavirus infections/diagnosis
KW - Measurement instrument
KW - Outcome assessment
UR - http://www.scopus.com/inward/record.url?scp=85090491621&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85090491621&partnerID=8YFLogxK
U2 - 10.1097/MCC.0000000000000750
DO - 10.1097/MCC.0000000000000750
M3 - Review article
C2 - 32773613
AN - SCOPUS:85090491621
VL - 26
SP - 489
EP - 499
JO - Current Opinion in Critical Care
JF - Current Opinion in Critical Care
SN - 1070-5295
IS - 5
ER -