Cord blood immune biomarkers in small for gestational age births

N. Matoba, F. Ouyang, K. K L Mestan, N. F M Porta, C. M. Pearson, K. M. Ortiz, H. C. Bauchner, B. S. Zuckerman, Xiaobin Wang

Research output: Contribution to journalArticle

Abstract

Fetal growth restriction is a risk factor for development of adulthood diseases, but the biological mechanism of this association remains unknown. Limited biomarkers have been studied in settings of preterm birth and maternal inflammation, but the relationship between a wide range of immune biomarkers and fetal growth has not been studied. The hypothesis of this study was that fetal growth restriction is associated with altered immune biomarker levels. We examined the relationship between small for gestational age (SGA) status and 27 umbilical cord blood immune biomarkers. This study was part of a large-scale cohort study of preterm birth and low birth weight conducted at Boston Medical Center, an inner city, predominantly minority patient population. Growth status was determined based on birth weight standardized to an internal reference. There were 74 SGA births and 319 appropriate for age (AGA) births with complete clinical and biomarker data. Adjusting for covariates and using AGA as reference, SGA births had lower levels of log IL-1β (ng/l; β 0.38, 95% CI 0.57, 0.19, P <0.01), log BDNF (β 0.29, 95% CI 0.55, 0.03, P <0.05) and log NT-3 (β 0.46, 95% CI 0.77, 0.15, P <0.01). No associations were found between other biomarkers and SGA. In conclusion, three biomarkers were selectively associated with SGA status. Our results provide information that could be used to guide additional studied aimed at determining mechanisms that contribute to fetal growth.

Original languageEnglish (US)
Pages (from-to)89-98
Number of pages10
JournalJournal of Developmental Origins of Health and Disease
Volume2
Issue number2
DOIs
StatePublished - Apr 2011
Externally publishedYes

Fingerprint

Fetal Blood
Gestational Age
Biomarkers
Parturition
Fetal Development
Premature Birth
Brain-Derived Neurotrophic Factor
Low Birth Weight Infant
Interleukin-1
Birth Weight
Cohort Studies
Mothers
Inflammation
Growth
Population

Keywords

  • fetal blood
  • infant
  • Key wordsbiological markers
  • small for gestational age

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Cord blood immune biomarkers in small for gestational age births. / Matoba, N.; Ouyang, F.; Mestan, K. K L; Porta, N. F M; Pearson, C. M.; Ortiz, K. M.; Bauchner, H. C.; Zuckerman, B. S.; Wang, Xiaobin.

In: Journal of Developmental Origins of Health and Disease, Vol. 2, No. 2, 04.2011, p. 89-98.

Research output: Contribution to journalArticle

Matoba, N, Ouyang, F, Mestan, KKL, Porta, NFM, Pearson, CM, Ortiz, KM, Bauchner, HC, Zuckerman, BS & Wang, X 2011, 'Cord blood immune biomarkers in small for gestational age births', Journal of Developmental Origins of Health and Disease, vol. 2, no. 2, pp. 89-98. https://doi.org/10.1017/S2040174411000018
Matoba, N. ; Ouyang, F. ; Mestan, K. K L ; Porta, N. F M ; Pearson, C. M. ; Ortiz, K. M. ; Bauchner, H. C. ; Zuckerman, B. S. ; Wang, Xiaobin. / Cord blood immune biomarkers in small for gestational age births. In: Journal of Developmental Origins of Health and Disease. 2011 ; Vol. 2, No. 2. pp. 89-98.
@article{841c4a812c824a90afb7a441183a6279,
title = "Cord blood immune biomarkers in small for gestational age births",
abstract = "Fetal growth restriction is a risk factor for development of adulthood diseases, but the biological mechanism of this association remains unknown. Limited biomarkers have been studied in settings of preterm birth and maternal inflammation, but the relationship between a wide range of immune biomarkers and fetal growth has not been studied. The hypothesis of this study was that fetal growth restriction is associated with altered immune biomarker levels. We examined the relationship between small for gestational age (SGA) status and 27 umbilical cord blood immune biomarkers. This study was part of a large-scale cohort study of preterm birth and low birth weight conducted at Boston Medical Center, an inner city, predominantly minority patient population. Growth status was determined based on birth weight standardized to an internal reference. There were 74 SGA births and 319 appropriate for age (AGA) births with complete clinical and biomarker data. Adjusting for covariates and using AGA as reference, SGA births had lower levels of log IL-1β (ng/l; β 0.38, 95{\%} CI 0.57, 0.19, P <0.01), log BDNF (β 0.29, 95{\%} CI 0.55, 0.03, P <0.05) and log NT-3 (β 0.46, 95{\%} CI 0.77, 0.15, P <0.01). No associations were found between other biomarkers and SGA. In conclusion, three biomarkers were selectively associated with SGA status. Our results provide information that could be used to guide additional studied aimed at determining mechanisms that contribute to fetal growth.",
keywords = "fetal blood, infant, Key wordsbiological markers, small for gestational age",
author = "N. Matoba and F. Ouyang and Mestan, {K. K L} and Porta, {N. F M} and Pearson, {C. M.} and Ortiz, {K. M.} and Bauchner, {H. C.} and Zuckerman, {B. S.} and Xiaobin Wang",
year = "2011",
month = "4",
doi = "10.1017/S2040174411000018",
language = "English (US)",
volume = "2",
pages = "89--98",
journal = "Journal of Developmental Origins of Health and Disease",
issn = "2040-1744",
publisher = "Cambridge University Press",
number = "2",

}

TY - JOUR

T1 - Cord blood immune biomarkers in small for gestational age births

AU - Matoba, N.

AU - Ouyang, F.

AU - Mestan, K. K L

AU - Porta, N. F M

AU - Pearson, C. M.

AU - Ortiz, K. M.

AU - Bauchner, H. C.

AU - Zuckerman, B. S.

AU - Wang, Xiaobin

PY - 2011/4

Y1 - 2011/4

N2 - Fetal growth restriction is a risk factor for development of adulthood diseases, but the biological mechanism of this association remains unknown. Limited biomarkers have been studied in settings of preterm birth and maternal inflammation, but the relationship between a wide range of immune biomarkers and fetal growth has not been studied. The hypothesis of this study was that fetal growth restriction is associated with altered immune biomarker levels. We examined the relationship between small for gestational age (SGA) status and 27 umbilical cord blood immune biomarkers. This study was part of a large-scale cohort study of preterm birth and low birth weight conducted at Boston Medical Center, an inner city, predominantly minority patient population. Growth status was determined based on birth weight standardized to an internal reference. There were 74 SGA births and 319 appropriate for age (AGA) births with complete clinical and biomarker data. Adjusting for covariates and using AGA as reference, SGA births had lower levels of log IL-1β (ng/l; β 0.38, 95% CI 0.57, 0.19, P <0.01), log BDNF (β 0.29, 95% CI 0.55, 0.03, P <0.05) and log NT-3 (β 0.46, 95% CI 0.77, 0.15, P <0.01). No associations were found between other biomarkers and SGA. In conclusion, three biomarkers were selectively associated with SGA status. Our results provide information that could be used to guide additional studied aimed at determining mechanisms that contribute to fetal growth.

AB - Fetal growth restriction is a risk factor for development of adulthood diseases, but the biological mechanism of this association remains unknown. Limited biomarkers have been studied in settings of preterm birth and maternal inflammation, but the relationship between a wide range of immune biomarkers and fetal growth has not been studied. The hypothesis of this study was that fetal growth restriction is associated with altered immune biomarker levels. We examined the relationship between small for gestational age (SGA) status and 27 umbilical cord blood immune biomarkers. This study was part of a large-scale cohort study of preterm birth and low birth weight conducted at Boston Medical Center, an inner city, predominantly minority patient population. Growth status was determined based on birth weight standardized to an internal reference. There were 74 SGA births and 319 appropriate for age (AGA) births with complete clinical and biomarker data. Adjusting for covariates and using AGA as reference, SGA births had lower levels of log IL-1β (ng/l; β 0.38, 95% CI 0.57, 0.19, P <0.01), log BDNF (β 0.29, 95% CI 0.55, 0.03, P <0.05) and log NT-3 (β 0.46, 95% CI 0.77, 0.15, P <0.01). No associations were found between other biomarkers and SGA. In conclusion, three biomarkers were selectively associated with SGA status. Our results provide information that could be used to guide additional studied aimed at determining mechanisms that contribute to fetal growth.

KW - fetal blood

KW - infant

KW - Key wordsbiological markers

KW - small for gestational age

UR - http://www.scopus.com/inward/record.url?scp=84867380498&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867380498&partnerID=8YFLogxK

U2 - 10.1017/S2040174411000018

DO - 10.1017/S2040174411000018

M3 - Article

C2 - 25140923

AN - SCOPUS:84867380498

VL - 2

SP - 89

EP - 98

JO - Journal of Developmental Origins of Health and Disease

JF - Journal of Developmental Origins of Health and Disease

SN - 2040-1744

IS - 2

ER -