Copy number variation in obsessive-compulsive disorder and tourette syndrome

A cross-disorder study

Lauren M. McGrath, Dongmei Yu, Christian Marshall, Lea K. Davis, Bhooma Thiruvahindrapuram, Bingbin Li, Carolina Cappi, Gloria Gerber, Aaron Wolf, Frederick A. Schroeder, Lisa Osiecki, Colm O'Dushlaine, Andrew Kirby, Cornelia Illmann, Stephen Haddad, Patience Gallagher, Jesen A. Fagerness, Cathy L. Barr, Laura Bellodi, Fortu Benarroch & 101 others Oscar J Bienvenu, Donald W. Black, Michael H. Bloch, Ruth D. Bruun, Cathy L. Budman, Beatriz Camarena, Danielle C. Cath, Maria C. Cavallini, Sylvain Chouinard, Vladimir Coric, Bernadette Cullen, Richard Delorme, Damiaan Denys, Eske M. Derks, Yves Dion, Maria C. Rosário, Valsama Eapen, Patrick Evans, Peter Falkai, Thomas V. Fernandez, Helena Garrido, Daniel Geller, Hans J. Grabe, Marco Grados, Benjamin D. Greenberg, Varda Gross-Tsur, Edna Grünblatt, Gary A. Heiman, Sian M J Hemmings, Luis D. Herrera, Ana G. Hounie, Joseph Jankovic, James L. Kennedy, Robert A. King, Roger Kurlan, Nuria Lanzagorta, Marion Leboyer, James F. Leckman, Leonhard Lennertz, Christine Lochner, Thomas L. Lowe, Gholson J. Lyon, Fabio MacCiardi, Wolfgang Maier, James T. McCracken, William McMahon, Dennis L. Murphy, Allan L. Naarden, Benjamin M. Neale, Erika Nurmi, Andrew J. Pakstis, Michele T. Pato, Carlos N. Pato, John Piacentini, Christopher Pittenger, Yehuda Pollak, Victor I. Reus, Margaret A. Richter, Mark A Riddle, Mary M. Robertson, David Rosenberg, Guy A. Rouleau, Stephan Ruhrmann, Aline S. Sampaio, Jack Samuels, Paul Sandor, Brooke Sheppard, Harvey Singer, Jan H. Smit, Dan J. Stein, Jay A. Tischfield, Homero Vallada, Jeremy Veenstra-Vanderweele, Susanne Walitza, Ying Wang, Jens R. Wendland, Yin Yao Shugart, Euripedes C. Miguel, Humberto Nicolini, Ben A. Oostra, Rainald Moessner, Michael Wagner, Andres Ruiz-Linares, Peter Heutink, Gerald Nestadt, Nelson Freimer, Tracey Petryshen, Danielle Posthuma, Michael A. Jenike, Nancy J. Cox, Gregory L. Hanna, Helena Brentani, Stephen W. Scherer, Paul D. Arnold, S. Evelyn Stewart, Carol A. Mathews, James A. Knowles, Edwin H. Cook, David L. Pauls, Kai Wang, Jeremiah M. Scharf

Research output: Contribution to journalArticle

Abstract

Objective Obsessive-compulsive disorder (OCD) and Tourette syndrome (TS) are heritable neurodevelopmental disorders with a partially shared genetic etiology. This study represents the first genome-wide investigation of large (>500 kb), rare (

Original languageEnglish (US)
Pages (from-to)910-919
Number of pages10
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume53
Issue number8
DOIs
StatePublished - 2014

Fingerprint

Tourette Syndrome
Obsessive-Compulsive Disorder
Genome
Neurodevelopmental Disorders

Keywords

  • 16p13.11
  • copy number variation
  • genetics
  • obsessive-compulsive disorder
  • Tourette syndrome

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Developmental and Educational Psychology
  • Medicine(all)

Cite this

Copy number variation in obsessive-compulsive disorder and tourette syndrome : A cross-disorder study. / McGrath, Lauren M.; Yu, Dongmei; Marshall, Christian; Davis, Lea K.; Thiruvahindrapuram, Bhooma; Li, Bingbin; Cappi, Carolina; Gerber, Gloria; Wolf, Aaron; Schroeder, Frederick A.; Osiecki, Lisa; O'Dushlaine, Colm; Kirby, Andrew; Illmann, Cornelia; Haddad, Stephen; Gallagher, Patience; Fagerness, Jesen A.; Barr, Cathy L.; Bellodi, Laura; Benarroch, Fortu; Bienvenu, Oscar J; Black, Donald W.; Bloch, Michael H.; Bruun, Ruth D.; Budman, Cathy L.; Camarena, Beatriz; Cath, Danielle C.; Cavallini, Maria C.; Chouinard, Sylvain; Coric, Vladimir; Cullen, Bernadette; Delorme, Richard; Denys, Damiaan; Derks, Eske M.; Dion, Yves; Rosário, Maria C.; Eapen, Valsama; Evans, Patrick; Falkai, Peter; Fernandez, Thomas V.; Garrido, Helena; Geller, Daniel; Grabe, Hans J.; Grados, Marco; Greenberg, Benjamin D.; Gross-Tsur, Varda; Grünblatt, Edna; Heiman, Gary A.; Hemmings, Sian M J; Herrera, Luis D.; Hounie, Ana G.; Jankovic, Joseph; Kennedy, James L.; King, Robert A.; Kurlan, Roger; Lanzagorta, Nuria; Leboyer, Marion; Leckman, James F.; Lennertz, Leonhard; Lochner, Christine; Lowe, Thomas L.; Lyon, Gholson J.; MacCiardi, Fabio; Maier, Wolfgang; McCracken, James T.; McMahon, William; Murphy, Dennis L.; Naarden, Allan L.; Neale, Benjamin M.; Nurmi, Erika; Pakstis, Andrew J.; Pato, Michele T.; Pato, Carlos N.; Piacentini, John; Pittenger, Christopher; Pollak, Yehuda; Reus, Victor I.; Richter, Margaret A.; Riddle, Mark A; Robertson, Mary M.; Rosenberg, David; Rouleau, Guy A.; Ruhrmann, Stephan; Sampaio, Aline S.; Samuels, Jack; Sandor, Paul; Sheppard, Brooke; Singer, Harvey; Smit, Jan H.; Stein, Dan J.; Tischfield, Jay A.; Vallada, Homero; Veenstra-Vanderweele, Jeremy; Walitza, Susanne; Wang, Ying; Wendland, Jens R.; Shugart, Yin Yao; Miguel, Euripedes C.; Nicolini, Humberto; Oostra, Ben A.; Moessner, Rainald; Wagner, Michael; Ruiz-Linares, Andres; Heutink, Peter; Nestadt, Gerald; Freimer, Nelson; Petryshen, Tracey; Posthuma, Danielle; Jenike, Michael A.; Cox, Nancy J.; Hanna, Gregory L.; Brentani, Helena; Scherer, Stephen W.; Arnold, Paul D.; Stewart, S. Evelyn; Mathews, Carol A.; Knowles, James A.; Cook, Edwin H.; Pauls, David L.; Wang, Kai; Scharf, Jeremiah M.

In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 53, No. 8, 2014, p. 910-919.

Research output: Contribution to journalArticle

McGrath, LM, Yu, D, Marshall, C, Davis, LK, Thiruvahindrapuram, B, Li, B, Cappi, C, Gerber, G, Wolf, A, Schroeder, FA, Osiecki, L, O'Dushlaine, C, Kirby, A, Illmann, C, Haddad, S, Gallagher, P, Fagerness, JA, Barr, CL, Bellodi, L, Benarroch, F, Bienvenu, OJ, Black, DW, Bloch, MH, Bruun, RD, Budman, CL, Camarena, B, Cath, DC, Cavallini, MC, Chouinard, S, Coric, V, Cullen, B, Delorme, R, Denys, D, Derks, EM, Dion, Y, Rosário, MC, Eapen, V, Evans, P, Falkai, P, Fernandez, TV, Garrido, H, Geller, D, Grabe, HJ, Grados, M, Greenberg, BD, Gross-Tsur, V, Grünblatt, E, Heiman, GA, Hemmings, SMJ, Herrera, LD, Hounie, AG, Jankovic, J, Kennedy, JL, King, RA, Kurlan, R, Lanzagorta, N, Leboyer, M, Leckman, JF, Lennertz, L, Lochner, C, Lowe, TL, Lyon, GJ, MacCiardi, F, Maier, W, McCracken, JT, McMahon, W, Murphy, DL, Naarden, AL, Neale, BM, Nurmi, E, Pakstis, AJ, Pato, MT, Pato, CN, Piacentini, J, Pittenger, C, Pollak, Y, Reus, VI, Richter, MA, Riddle, MA, Robertson, MM, Rosenberg, D, Rouleau, GA, Ruhrmann, S, Sampaio, AS, Samuels, J, Sandor, P, Sheppard, B, Singer, H, Smit, JH, Stein, DJ, Tischfield, JA, Vallada, H, Veenstra-Vanderweele, J, Walitza, S, Wang, Y, Wendland, JR, Shugart, YY, Miguel, EC, Nicolini, H, Oostra, BA, Moessner, R, Wagner, M, Ruiz-Linares, A, Heutink, P, Nestadt, G, Freimer, N, Petryshen, T, Posthuma, D, Jenike, MA, Cox, NJ, Hanna, GL, Brentani, H, Scherer, SW, Arnold, PD, Stewart, SE, Mathews, CA, Knowles, JA, Cook, EH, Pauls, DL, Wang, K & Scharf, JM 2014, 'Copy number variation in obsessive-compulsive disorder and tourette syndrome: A cross-disorder study', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 53, no. 8, pp. 910-919. https://doi.org/10.1016/j.jaac.2014.04.022
McGrath, Lauren M. ; Yu, Dongmei ; Marshall, Christian ; Davis, Lea K. ; Thiruvahindrapuram, Bhooma ; Li, Bingbin ; Cappi, Carolina ; Gerber, Gloria ; Wolf, Aaron ; Schroeder, Frederick A. ; Osiecki, Lisa ; O'Dushlaine, Colm ; Kirby, Andrew ; Illmann, Cornelia ; Haddad, Stephen ; Gallagher, Patience ; Fagerness, Jesen A. ; Barr, Cathy L. ; Bellodi, Laura ; Benarroch, Fortu ; Bienvenu, Oscar J ; Black, Donald W. ; Bloch, Michael H. ; Bruun, Ruth D. ; Budman, Cathy L. ; Camarena, Beatriz ; Cath, Danielle C. ; Cavallini, Maria C. ; Chouinard, Sylvain ; Coric, Vladimir ; Cullen, Bernadette ; Delorme, Richard ; Denys, Damiaan ; Derks, Eske M. ; Dion, Yves ; Rosário, Maria C. ; Eapen, Valsama ; Evans, Patrick ; Falkai, Peter ; Fernandez, Thomas V. ; Garrido, Helena ; Geller, Daniel ; Grabe, Hans J. ; Grados, Marco ; Greenberg, Benjamin D. ; Gross-Tsur, Varda ; Grünblatt, Edna ; Heiman, Gary A. ; Hemmings, Sian M J ; Herrera, Luis D. ; Hounie, Ana G. ; Jankovic, Joseph ; Kennedy, James L. ; King, Robert A. ; Kurlan, Roger ; Lanzagorta, Nuria ; Leboyer, Marion ; Leckman, James F. ; Lennertz, Leonhard ; Lochner, Christine ; Lowe, Thomas L. ; Lyon, Gholson J. ; MacCiardi, Fabio ; Maier, Wolfgang ; McCracken, James T. ; McMahon, William ; Murphy, Dennis L. ; Naarden, Allan L. ; Neale, Benjamin M. ; Nurmi, Erika ; Pakstis, Andrew J. ; Pato, Michele T. ; Pato, Carlos N. ; Piacentini, John ; Pittenger, Christopher ; Pollak, Yehuda ; Reus, Victor I. ; Richter, Margaret A. ; Riddle, Mark A ; Robertson, Mary M. ; Rosenberg, David ; Rouleau, Guy A. ; Ruhrmann, Stephan ; Sampaio, Aline S. ; Samuels, Jack ; Sandor, Paul ; Sheppard, Brooke ; Singer, Harvey ; Smit, Jan H. ; Stein, Dan J. ; Tischfield, Jay A. ; Vallada, Homero ; Veenstra-Vanderweele, Jeremy ; Walitza, Susanne ; Wang, Ying ; Wendland, Jens R. ; Shugart, Yin Yao ; Miguel, Euripedes C. ; Nicolini, Humberto ; Oostra, Ben A. ; Moessner, Rainald ; Wagner, Michael ; Ruiz-Linares, Andres ; Heutink, Peter ; Nestadt, Gerald ; Freimer, Nelson ; Petryshen, Tracey ; Posthuma, Danielle ; Jenike, Michael A. ; Cox, Nancy J. ; Hanna, Gregory L. ; Brentani, Helena ; Scherer, Stephen W. ; Arnold, Paul D. ; Stewart, S. Evelyn ; Mathews, Carol A. ; Knowles, James A. ; Cook, Edwin H. ; Pauls, David L. ; Wang, Kai ; Scharf, Jeremiah M. / Copy number variation in obsessive-compulsive disorder and tourette syndrome : A cross-disorder study. In: Journal of the American Academy of Child and Adolescent Psychiatry. 2014 ; Vol. 53, No. 8. pp. 910-919.
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AU - McGrath, Lauren M.

AU - Yu, Dongmei

AU - Marshall, Christian

AU - Davis, Lea K.

AU - Thiruvahindrapuram, Bhooma

AU - Li, Bingbin

AU - Cappi, Carolina

AU - Gerber, Gloria

AU - Wolf, Aaron

AU - Schroeder, Frederick A.

AU - Osiecki, Lisa

AU - O'Dushlaine, Colm

AU - Kirby, Andrew

AU - Illmann, Cornelia

AU - Haddad, Stephen

AU - Gallagher, Patience

AU - Fagerness, Jesen A.

AU - Barr, Cathy L.

AU - Bellodi, Laura

AU - Benarroch, Fortu

AU - Bienvenu, Oscar J

AU - Black, Donald W.

AU - Bloch, Michael H.

AU - Bruun, Ruth D.

AU - Budman, Cathy L.

AU - Camarena, Beatriz

AU - Cath, Danielle C.

AU - Cavallini, Maria C.

AU - Chouinard, Sylvain

AU - Coric, Vladimir

AU - Cullen, Bernadette

AU - Delorme, Richard

AU - Denys, Damiaan

AU - Derks, Eske M.

AU - Dion, Yves

AU - Rosário, Maria C.

AU - Eapen, Valsama

AU - Evans, Patrick

AU - Falkai, Peter

AU - Fernandez, Thomas V.

AU - Garrido, Helena

AU - Geller, Daniel

AU - Grabe, Hans J.

AU - Grados, Marco

AU - Greenberg, Benjamin D.

AU - Gross-Tsur, Varda

AU - Grünblatt, Edna

AU - Heiman, Gary A.

AU - Hemmings, Sian M J

AU - Herrera, Luis D.

AU - Hounie, Ana G.

AU - Jankovic, Joseph

AU - Kennedy, James L.

AU - King, Robert A.

AU - Kurlan, Roger

AU - Lanzagorta, Nuria

AU - Leboyer, Marion

AU - Leckman, James F.

AU - Lennertz, Leonhard

AU - Lochner, Christine

AU - Lowe, Thomas L.

AU - Lyon, Gholson J.

AU - MacCiardi, Fabio

AU - Maier, Wolfgang

AU - McCracken, James T.

AU - McMahon, William

AU - Murphy, Dennis L.

AU - Naarden, Allan L.

AU - Neale, Benjamin M.

AU - Nurmi, Erika

AU - Pakstis, Andrew J.

AU - Pato, Michele T.

AU - Pato, Carlos N.

AU - Piacentini, John

AU - Pittenger, Christopher

AU - Pollak, Yehuda

AU - Reus, Victor I.

AU - Richter, Margaret A.

AU - Riddle, Mark A

AU - Robertson, Mary M.

AU - Rosenberg, David

AU - Rouleau, Guy A.

AU - Ruhrmann, Stephan

AU - Sampaio, Aline S.

AU - Samuels, Jack

AU - Sandor, Paul

AU - Sheppard, Brooke

AU - Singer, Harvey

AU - Smit, Jan H.

AU - Stein, Dan J.

AU - Tischfield, Jay A.

AU - Vallada, Homero

AU - Veenstra-Vanderweele, Jeremy

AU - Walitza, Susanne

AU - Wang, Ying

AU - Wendland, Jens R.

AU - Shugart, Yin Yao

AU - Miguel, Euripedes C.

AU - Nicolini, Humberto

AU - Oostra, Ben A.

AU - Moessner, Rainald

AU - Wagner, Michael

AU - Ruiz-Linares, Andres

AU - Heutink, Peter

AU - Nestadt, Gerald

AU - Freimer, Nelson

AU - Petryshen, Tracey

AU - Posthuma, Danielle

AU - Jenike, Michael A.

AU - Cox, Nancy J.

AU - Hanna, Gregory L.

AU - Brentani, Helena

AU - Scherer, Stephen W.

AU - Arnold, Paul D.

AU - Stewart, S. Evelyn

AU - Mathews, Carol A.

AU - Knowles, James A.

AU - Cook, Edwin H.

AU - Pauls, David L.

AU - Wang, Kai

AU - Scharf, Jeremiah M.

PY - 2014

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KW - copy number variation

KW - genetics

KW - obsessive-compulsive disorder

KW - Tourette syndrome

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