TY - JOUR
T1 - Copper(II) complexes of deltakephalin and its analogues containing α-hydroxymethylserine
AU - Kowalik-Jankowska, Teresa
AU - Leśniak, Wojciech
AU - Brasuń, Justyna
AU - Stasiak, Marcin
AU - Leplawy, Mirosław T.
N1 - Funding Information:
This work was financially supported by the University of Wrocław, grant 2015/W/WCH/98/2. M.T.L. acknowledges support from the Polish Committee for Scientific Research (grant 3TO9A-11108).
PY - 2000/1/30
Y1 - 2000/1/30
N2 - Potentiometric and spectroscopic data have shown that deltakephalin and its derivatives containing the α-hydroxymethylserine (HmS) residue in the second and in the second and sixth positions form the same series of complexes: CuHL, CuL, CuH-1L, CuH-2L and CuH-3L (1N to 4N binding mode). The alcoholic groups in the amino acid side chain are very effective in the stabilization of the complexes formed (the protonation corrected stability constants, log K* values of 4N complexes are -22.55 and -21.15 for deltakephalin and its derivative containing the HmS residue in the second and sixth positions, respectively). There is no evidence for the direct involvement of alcoholic groups of HmS in binding of Cu2+ ions and there is no indication of binding through the tyrosine-phenolate oxygen atoms, either. (C) 2000 Elsevier Science Ltd.
AB - Potentiometric and spectroscopic data have shown that deltakephalin and its derivatives containing the α-hydroxymethylserine (HmS) residue in the second and in the second and sixth positions form the same series of complexes: CuHL, CuL, CuH-1L, CuH-2L and CuH-3L (1N to 4N binding mode). The alcoholic groups in the amino acid side chain are very effective in the stabilization of the complexes formed (the protonation corrected stability constants, log K* values of 4N complexes are -22.55 and -21.15 for deltakephalin and its derivative containing the HmS residue in the second and sixth positions, respectively). There is no evidence for the direct involvement of alcoholic groups of HmS in binding of Cu2+ ions and there is no indication of binding through the tyrosine-phenolate oxygen atoms, either. (C) 2000 Elsevier Science Ltd.
KW - Copper(II) complexes
KW - Deltakephalins
KW - Stability constants
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U2 - 10.1016/S0277-5387(99)00377-0
DO - 10.1016/S0277-5387(99)00377-0
M3 - Article
AN - SCOPUS:0034731771
SN - 0277-5387
VL - 19
SP - 241
EP - 245
JO - Polyhedron
JF - Polyhedron
IS - 2
ER -