Copper(II) complexes of deltakephalin and its analogues containing α-hydroxymethylserine

Teresa Kowalik-Jankowska, Wojciech Lesniak, Justyna Brasuń, Marcin Stasiak, Mirosław T. Leplawy

Research output: Contribution to journalArticle

Abstract

Potentiometric and spectroscopic data have shown that deltakephalin and its derivatives containing the α-hydroxymethylserine (HmS) residue in the second and in the second and sixth positions form the same series of complexes: CuHL, CuL, CuH-1L, CuH-2L and CuH-3L (1N to 4N binding mode). The alcoholic groups in the amino acid side chain are very effective in the stabilization of the complexes formed (the protonation corrected stability constants, log K* values of 4N complexes are -22.55 and -21.15 for deltakephalin and its derivative containing the HmS residue in the second and sixth positions, respectively). There is no evidence for the direct involvement of alcoholic groups of HmS in binding of Cu2+ ions and there is no indication of binding through the tyrosine-phenolate oxygen atoms, either. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)241-245
Number of pages5
JournalPolyhedron
Volume19
Issue number2
StatePublished - Jan 30 2000
Externally publishedYes

Fingerprint

Copper
analogs
Derivatives
copper
Protonation
Tyrosine
Amino acids
Stabilization
tyrosine
Ions
Oxygen
Amino Acids
Atoms
amino acids
oxygen atoms
indication
stabilization
deltakephalin
ions

Keywords

  • Copper(II) complexes
  • Deltakephalins
  • Stability constants

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Cite this

Kowalik-Jankowska, T., Lesniak, W., Brasuń, J., Stasiak, M., & Leplawy, M. T. (2000). Copper(II) complexes of deltakephalin and its analogues containing α-hydroxymethylserine. Polyhedron, 19(2), 241-245.

Copper(II) complexes of deltakephalin and its analogues containing α-hydroxymethylserine. / Kowalik-Jankowska, Teresa; Lesniak, Wojciech; Brasuń, Justyna; Stasiak, Marcin; Leplawy, Mirosław T.

In: Polyhedron, Vol. 19, No. 2, 30.01.2000, p. 241-245.

Research output: Contribution to journalArticle

Kowalik-Jankowska, T, Lesniak, W, Brasuń, J, Stasiak, M & Leplawy, MT 2000, 'Copper(II) complexes of deltakephalin and its analogues containing α-hydroxymethylserine', Polyhedron, vol. 19, no. 2, pp. 241-245.
Kowalik-Jankowska T, Lesniak W, Brasuń J, Stasiak M, Leplawy MT. Copper(II) complexes of deltakephalin and its analogues containing α-hydroxymethylserine. Polyhedron. 2000 Jan 30;19(2):241-245.
Kowalik-Jankowska, Teresa ; Lesniak, Wojciech ; Brasuń, Justyna ; Stasiak, Marcin ; Leplawy, Mirosław T. / Copper(II) complexes of deltakephalin and its analogues containing α-hydroxymethylserine. In: Polyhedron. 2000 ; Vol. 19, No. 2. pp. 241-245.
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AU - Stasiak, Marcin

AU - Leplawy, Mirosław T.

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AB - Potentiometric and spectroscopic data have shown that deltakephalin and its derivatives containing the α-hydroxymethylserine (HmS) residue in the second and in the second and sixth positions form the same series of complexes: CuHL, CuL, CuH-1L, CuH-2L and CuH-3L (1N to 4N binding mode). The alcoholic groups in the amino acid side chain are very effective in the stabilization of the complexes formed (the protonation corrected stability constants, log K* values of 4N complexes are -22.55 and -21.15 for deltakephalin and its derivative containing the HmS residue in the second and sixth positions, respectively). There is no evidence for the direct involvement of alcoholic groups of HmS in binding of Cu2+ ions and there is no indication of binding through the tyrosine-phenolate oxygen atoms, either. (C) 2000 Elsevier Science Ltd.

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