Abstract
Copper plays an essential role in human physiology. It is required for respiration, radical defense, neuronal myelination, angiogenesis, and many other processes. Copper has distinct physicochemical properties that pose uncommon challenges for its transport across biological membranes. Only small amounts of copper are present in biological fluids, and essentially none of it exists in a free ion form. These properties and the low redox potential of copper dictate special structural and mechanistic features in copper transporters. This minireview discusses molecular mechanisms through which copper enters and exits human cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 25461-25465 |
| Number of pages | 5 |
| Journal | Journal of Biological Chemistry |
| Volume | 284 |
| Issue number | 38 |
| DOIs | |
| State | Published - Sep 18 2009 |
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ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology
- Medicine(all)
Cite this
Copper transport in mammalian cells : Special care for a metal with special needs. / Kaplan, Jack H.; Lutsenko, Svetlana.
In: Journal of Biological Chemistry, Vol. 284, No. 38, 18.09.2009, p. 25461-25465.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Copper transport in mammalian cells
T2 - Special care for a metal with special needs
AU - Kaplan, Jack H.
AU - Lutsenko, Svetlana
PY - 2009/9/18
Y1 - 2009/9/18
N2 - Copper plays an essential role in human physiology. It is required for respiration, radical defense, neuronal myelination, angiogenesis, and many other processes. Copper has distinct physicochemical properties that pose uncommon challenges for its transport across biological membranes. Only small amounts of copper are present in biological fluids, and essentially none of it exists in a free ion form. These properties and the low redox potential of copper dictate special structural and mechanistic features in copper transporters. This minireview discusses molecular mechanisms through which copper enters and exits human cells.
AB - Copper plays an essential role in human physiology. It is required for respiration, radical defense, neuronal myelination, angiogenesis, and many other processes. Copper has distinct physicochemical properties that pose uncommon challenges for its transport across biological membranes. Only small amounts of copper are present in biological fluids, and essentially none of it exists in a free ion form. These properties and the low redox potential of copper dictate special structural and mechanistic features in copper transporters. This minireview discusses molecular mechanisms through which copper enters and exits human cells.
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UR - http://www.scopus.com/inward/citedby.url?scp=70350029582&partnerID=8YFLogxK
U2 - 10.1074/jbc.R109.031286
DO - 10.1074/jbc.R109.031286
M3 - Article
C2 - 19602511
AN - SCOPUS:70350029582
VL - 284
SP - 25461
EP - 25465
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 38
ER -