Copper transport in mammalian cells: Special care for a metal with special needs

Jack H. Kaplan, Svetlana Lutsenko

Research output: Contribution to journalArticle

Abstract

Copper plays an essential role in human physiology. It is required for respiration, radical defense, neuronal myelination, angiogenesis, and many other processes. Copper has distinct physicochemical properties that pose uncommon challenges for its transport across biological membranes. Only small amounts of copper are present in biological fluids, and essentially none of it exists in a free ion form. These properties and the low redox potential of copper dictate special structural and mechanistic features in copper transporters. This minireview discusses molecular mechanisms through which copper enters and exits human cells.

Original languageEnglish (US)
Pages (from-to)25461-25465
Number of pages5
JournalJournal of Biological Chemistry
Volume284
Issue number38
DOIs
StatePublished - Sep 18 2009

Fingerprint

Copper
Metals
Cells
Biological Transport
Biological membranes
Physiology
Oxidation-Reduction
Respiration
Ions
Fluids
Membranes

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

Copper transport in mammalian cells : Special care for a metal with special needs. / Kaplan, Jack H.; Lutsenko, Svetlana.

In: Journal of Biological Chemistry, Vol. 284, No. 38, 18.09.2009, p. 25461-25465.

Research output: Contribution to journalArticle

@article{fb58cc49dcef419b883e70576b3ead4c,
title = "Copper transport in mammalian cells: Special care for a metal with special needs",
abstract = "Copper plays an essential role in human physiology. It is required for respiration, radical defense, neuronal myelination, angiogenesis, and many other processes. Copper has distinct physicochemical properties that pose uncommon challenges for its transport across biological membranes. Only small amounts of copper are present in biological fluids, and essentially none of it exists in a free ion form. These properties and the low redox potential of copper dictate special structural and mechanistic features in copper transporters. This minireview discusses molecular mechanisms through which copper enters and exits human cells.",
author = "Kaplan, {Jack H.} and Svetlana Lutsenko",
year = "2009",
month = "9",
day = "18",
doi = "10.1074/jbc.R109.031286",
language = "English (US)",
volume = "284",
pages = "25461--25465",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "38",

}

TY - JOUR

T1 - Copper transport in mammalian cells

T2 - Special care for a metal with special needs

AU - Kaplan, Jack H.

AU - Lutsenko, Svetlana

PY - 2009/9/18

Y1 - 2009/9/18

N2 - Copper plays an essential role in human physiology. It is required for respiration, radical defense, neuronal myelination, angiogenesis, and many other processes. Copper has distinct physicochemical properties that pose uncommon challenges for its transport across biological membranes. Only small amounts of copper are present in biological fluids, and essentially none of it exists in a free ion form. These properties and the low redox potential of copper dictate special structural and mechanistic features in copper transporters. This minireview discusses molecular mechanisms through which copper enters and exits human cells.

AB - Copper plays an essential role in human physiology. It is required for respiration, radical defense, neuronal myelination, angiogenesis, and many other processes. Copper has distinct physicochemical properties that pose uncommon challenges for its transport across biological membranes. Only small amounts of copper are present in biological fluids, and essentially none of it exists in a free ion form. These properties and the low redox potential of copper dictate special structural and mechanistic features in copper transporters. This minireview discusses molecular mechanisms through which copper enters and exits human cells.

UR - http://www.scopus.com/inward/record.url?scp=70350029582&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350029582&partnerID=8YFLogxK

U2 - 10.1074/jbc.R109.031286

DO - 10.1074/jbc.R109.031286

M3 - Article

C2 - 19602511

AN - SCOPUS:70350029582

VL - 284

SP - 25461

EP - 25465

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 38

ER -