Copper-free click—a promising tool for pre-targeted PET imaging

Helen L. Evans, Rozanna L. Slade, Laurence Carroll, Graham Smith, Quang De Nguyen, Lisa Iddon, Nazila Kamaly, Henning Stöckmann, Finian J. Leeper, Eric O. Aboagye, Alan C. Spivey

Research output: Contribution to journalArticlepeer-review


The copper-free click (CFC) reaction has been evaluated for its potential application to in vivo pre-targeting for PET imaging. A promising biodistribution profile is demonstrated when employing [18F]2-fluoroethylazide ([18F]1) and optimisation of the CFC reaction with a series of cyclooctynes shows that reactions proceed efficiently with tantalizing opportunities for application-specific tuning.

Original languageEnglish (US)
Pages (from-to)991-993
Number of pages3
JournalChemical Communications
Issue number7
StatePublished - Jan 3 2012
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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