Copper-free click—a promising tool for pre-targeted PET imaging

Helen L. Evans; Rozanna L. Slade; Laurence Carroll; Graham Smith; Quang De Nguyen; Lisa Iddon; Nazila Kamaly; Henning Stöckmann; Finian J. Leeper; Eric O. Aboagye; Alan C. Spivey

doi:10.1039/c1cc16220a

Copper-free click—a promising tool for pre-targeted PET imaging

Helen L. Evans, Rozanna L. Slade, Laurence Carroll, Graham Smith, Quang De Nguyen, Lisa Iddon, Nazila Kamaly, Henning Stöckmann, Finian J. Leeper, Eric O. Aboagye, Alan C. Spivey

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

The copper-free click (CFC) reaction has been evaluated for its potential application to in vivo pre-targeting for PET imaging. A promising biodistribution profile is demonstrated when employing [¹⁸F]2-fluoroethylazide ([¹⁸F]1) and optimisation of the CFC reaction with a series of cyclooctynes shows that reactions proceed efficiently with tantalizing opportunities for application-specific tuning.

Original language	English (US)
Pages (from-to)	991-993
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	7
DOIs	https://doi.org/10.1039/c1cc16220a
State	Published - Jan 3 2012
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "The copper-free click (CFC) reaction has been evaluated for its potential application to in vivo pre-targeting for PET imaging. A promising biodistribution profile is demonstrated when employing [18F]2-fluoroethylazide ([18F]1) and optimisation of the CFC reaction with a series of cyclooctynes shows that reactions proceed efficiently with tantalizing opportunities for application-specific tuning.",

author = "Evans, {Helen L.} and Slade, {Rozanna L.} and Laurence Carroll and Graham Smith and Nguyen, {Quang De} and Lisa Iddon and Nazila Kamaly and Henning St{\"o}ckmann and Leeper, {Finian J.} and Aboagye, {Eric O.} and Spivey, {Alan C.}",

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AU - Evans, Helen L.

AU - Slade, Rozanna L.

AU - Carroll, Laurence

AU - Smith, Graham

AU - Nguyen, Quang De

AU - Iddon, Lisa

AU - Kamaly, Nazila

AU - Stöckmann, Henning

AU - Leeper, Finian J.

AU - Aboagye, Eric O.

AU - Spivey, Alan C.

PY - 2012/1/3

Y1 - 2012/1/3

N2 - The copper-free click (CFC) reaction has been evaluated for its potential application to in vivo pre-targeting for PET imaging. A promising biodistribution profile is demonstrated when employing [18F]2-fluoroethylazide ([18F]1) and optimisation of the CFC reaction with a series of cyclooctynes shows that reactions proceed efficiently with tantalizing opportunities for application-specific tuning.

AB - The copper-free click (CFC) reaction has been evaluated for its potential application to in vivo pre-targeting for PET imaging. A promising biodistribution profile is demonstrated when employing [18F]2-fluoroethylazide ([18F]1) and optimisation of the CFC reaction with a series of cyclooctynes shows that reactions proceed efficiently with tantalizing opportunities for application-specific tuning.

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Copper-free click—a promising tool for pre-targeted PET imaging

Abstract

ASJC Scopus subject areas

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