Copper dipicolinates as peptidomimetic ligands for the Src SH2 domain

Boris Schmidt, Jan Jiricek, Alexander Titz, Guofeng Ye, Keykavous Parang

Research output: Contribution to journalArticle

Abstract

The introduction of copper chelates into peptide mimetics creates the Src SH2 binding ligands and paramagnetic complexes suitable for EPR studies of peptide protein interactions. The dipicolinic acid was attached to SH2 domain targeting fragments by two different linkers.

Original languageEnglish (US)
Pages (from-to)4203-4206
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number16
DOIs
StatePublished - Aug 16 2004
Externally publishedYes

Fingerprint

Peptidomimetics
src Homology Domains
Copper
Ligands
Peptides
Paramagnetic resonance
Proteins
dipicolinic acid

Keywords

  • Copper complex
  • ESR
  • Peptide mimetic
  • SH2 domain

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Copper dipicolinates as peptidomimetic ligands for the Src SH2 domain. / Schmidt, Boris; Jiricek, Jan; Titz, Alexander; Ye, Guofeng; Parang, Keykavous.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 14, No. 16, 16.08.2004, p. 4203-4206.

Research output: Contribution to journalArticle

Schmidt, Boris ; Jiricek, Jan ; Titz, Alexander ; Ye, Guofeng ; Parang, Keykavous. / Copper dipicolinates as peptidomimetic ligands for the Src SH2 domain. In: Bioorganic and Medicinal Chemistry Letters. 2004 ; Vol. 14, No. 16. pp. 4203-4206.
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