Copper dipicolinates as peptidomimetic ligands for the Src SH2 domain

Boris Schmidt; Jan Jiricek; Alexander Titz; Guofeng Ye; Keykavous Parang

doi:10.1016/j.bmcl.2004.06.018

Copper dipicolinates as peptidomimetic ligands for the Src SH2 domain

Boris Schmidt, Jan Jiricek, Alexander Titz, Guofeng Ye, Keykavous Parang

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The introduction of copper chelates into peptide mimetics creates the Src SH2 binding ligands and paramagnetic complexes suitable for EPR studies of peptide protein interactions. The dipicolinic acid was attached to SH2 domain targeting fragments by two different linkers.

Original language	English (US)
Pages (from-to)	4203-4206
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	16
DOIs	https://doi.org/10.1016/j.bmcl.2004.06.018
State	Published - Aug 16 2004
Externally published	Yes

Keywords

Copper complex
ESR
Peptide mimetic
SH2 domain

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Organic Chemistry
Drug Discovery
Pharmaceutical Science

Access to Document

10.1016/j.bmcl.2004.06.018

Cite this

@article{fb47af3e4624425abe7ddb5fd6d4399f,

title = "Copper dipicolinates as peptidomimetic ligands for the Src SH2 domain",

abstract = "The introduction of copper chelates into peptide mimetics creates the Src SH2 binding ligands and paramagnetic complexes suitable for EPR studies of peptide protein interactions. The dipicolinic acid was attached to SH2 domain targeting fragments by two different linkers.",

keywords = "Copper complex, ESR, Peptide mimetic, SH2 domain",

author = "Boris Schmidt and Jan Jiricek and Alexander Titz and Guofeng Ye and Keykavous Parang",

year = "2004",

month = aug,

day = "16",

doi = "10.1016/j.bmcl.2004.06.018",

language = "English (US)",

volume = "14",

pages = "4203--4206",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "16",

}

TY - JOUR

T1 - Copper dipicolinates as peptidomimetic ligands for the Src SH2 domain

AU - Schmidt, Boris

AU - Jiricek, Jan

AU - Titz, Alexander

AU - Ye, Guofeng

AU - Parang, Keykavous

PY - 2004/8/16

Y1 - 2004/8/16

N2 - The introduction of copper chelates into peptide mimetics creates the Src SH2 binding ligands and paramagnetic complexes suitable for EPR studies of peptide protein interactions. The dipicolinic acid was attached to SH2 domain targeting fragments by two different linkers.

AB - The introduction of copper chelates into peptide mimetics creates the Src SH2 binding ligands and paramagnetic complexes suitable for EPR studies of peptide protein interactions. The dipicolinic acid was attached to SH2 domain targeting fragments by two different linkers.

KW - Copper complex

KW - ESR

KW - Peptide mimetic

KW - SH2 domain

UR - http://www.scopus.com/inward/record.url?scp=3142758554&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3142758554&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2004.06.018

DO - 10.1016/j.bmcl.2004.06.018

M3 - Article

C2 - 15261270

AN - SCOPUS:3142758554

SN - 0960-894X

VL - 14

SP - 4203

EP - 4206

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 16

ER -

Copper dipicolinates as peptidomimetic ligands for the Src SH2 domain

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this