Copolymer-1-induced inhibition of antigen-specific T cell activation: interference with antigen presentation

Michael K. Racke, Roland Martin, Henry McFarland, Robert B. Fritz

Research output: Contribution to journalArticle

Abstract

Copolymer-1 (Cop-1) has been shown to inhibit in vivo development of experimental allergic encephalomyelitis (EAE) in animals and has been reported to have some therapeutic benefit in relapsing/remitting multiple sclerosis (MS). The mechanism by which Cop-1 acts in vivo is not known. The present study demonstrates that Cop-1 inhibits the in vitro response of several antigen-specific murine T cell hybridomas restricted to I-A, and to a lesser extent, I-E. The ability of human myelin basic protein (MBP)-specific T cell lines (TCL) to lyse targets in the context of three HLA-DR types associated with MS was also impaired by Cop-1. The results suggest that the observed inhibition was due to competition between Cop-1 and nominal antigen for the class II major histocompatibility complex (MHC) peptide binding site.

Original languageEnglish (US)
Pages (from-to)75-84
Number of pages10
JournalJournal of Neuroimmunology
Volume37
Issue number1-2
DOIs
StatePublished - 1992
Externally publishedYes

Keywords

  • Antigen presentation
  • Copolymer-1
  • Experimental allergic encephalomyelitis
  • Multiple sclerosis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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