Coordinated movements of eukaryotic translation initiation Factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complex

Jagpreet S. Nanda, Adesh K. Saini, Antonio M. Muñoz, Alan G. Hinnebusch, Jon R. Lorsch

Research output: Contribution to journalArticle

Abstract

Background: Start codon recognition triggers eIF1 and Pi release from the preinitiation complex. Results: The C-terminal tail of eIF1A moves closer to eIF5 upon start codon recognition, and this movement is required for Pi release. Conclusion: eIF1 release and movement of the eIF1A C-terminal tail toward eIF5 are coupled processes. Significance: Start codon recognition induces coordinated movements of initiation factors that trigger downstream events.

Original languageEnglish (US)
Pages (from-to)5316-5329
Number of pages14
JournalJournal of Biological Chemistry
Volume288
Issue number8
DOIs
StatePublished - Feb 22 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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