TY - GEN
T1 - Cooperative interactions between myosin II and cortexillin I mediated by actin filaments during cellular deformation
AU - Luo, Tianzhi
AU - Robinson, Douglas N.
PY - 2010/11/8
Y1 - 2010/11/8
N2 - A mechanosensory system consisting non-muscle myosin II, cortexillin I, and actin filaments has been identified recently. During cellular deformation, myosin II and cortexillin cooperatively accumulate in highly deformed region in response to the applied stress and the extent of accumulation increases with increased stress. The cooperativity is suggested to be mediated by the actin filaments. The accumulation of these proteins increases the mechanical resistance of the cells to against the external load, leading to a diminishing deformation.
AB - A mechanosensory system consisting non-muscle myosin II, cortexillin I, and actin filaments has been identified recently. During cellular deformation, myosin II and cortexillin cooperatively accumulate in highly deformed region in response to the applied stress and the extent of accumulation increases with increased stress. The cooperativity is suggested to be mediated by the actin filaments. The accumulation of these proteins increases the mechanical resistance of the cells to against the external load, leading to a diminishing deformation.
KW - Actin
KW - Actin cross-linking protein
KW - Mechanosensing
KW - Myosin
UR - http://www.scopus.com/inward/record.url?scp=78049401995&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78049401995&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-14998-6_20
DO - 10.1007/978-3-642-14998-6_20
M3 - Conference contribution
AN - SCOPUS:78049401995
SN - 9783642149979
T3 - IFMBE Proceedings
SP - 74
EP - 76
BT - 26th Southern Biomedical Engineering Conference SBEC 2010
T2 - 26th Southern Biomedical Engineering Conference, SBEC 2010
Y2 - 30 April 2010 through 2 May 2010
ER -