Cooperative interactions between myosin II and cortexillin I mediated by actin filaments during cellular deformation

Tianzhi Luo, Douglas N. Robinson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A mechanosensory system consisting non-muscle myosin II, cortexillin I, and actin filaments has been identified recently. During cellular deformation, myosin II and cortexillin cooperatively accumulate in highly deformed region in response to the applied stress and the extent of accumulation increases with increased stress. The cooperativity is suggested to be mediated by the actin filaments. The accumulation of these proteins increases the mechanical resistance of the cells to against the external load, leading to a diminishing deformation.

Original languageEnglish (US)
Title of host publication26th Southern Biomedical Engineering Conference SBEC 2010
Pages74-76
Number of pages3
DOIs
StatePublished - Nov 8 2010
Event26th Southern Biomedical Engineering Conference, SBEC 2010 - College Park, MD, United States
Duration: Apr 30 2010May 2 2010

Publication series

NameIFMBE Proceedings
Volume32 IFMBE
ISSN (Print)1680-0737

Other

Other26th Southern Biomedical Engineering Conference, SBEC 2010
CountryUnited States
CityCollege Park, MD
Period4/30/105/2/10

Keywords

  • Actin
  • Actin cross-linking protein
  • Mechanosensing
  • Myosin

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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  • Cite this

    Luo, T., & Robinson, D. N. (2010). Cooperative interactions between myosin II and cortexillin I mediated by actin filaments during cellular deformation. In 26th Southern Biomedical Engineering Conference SBEC 2010 (pp. 74-76). (IFMBE Proceedings; Vol. 32 IFMBE). https://doi.org/10.1007/978-3-642-14998-6_20