Cooperative interactions between myosin II and cortexillin I mediated by actin filaments during cellular deformation

Tianzhi Luo, Douglas Robinson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A mechanosensory system consisting non-muscle myosin II, cortexillin I, and actin filaments has been identified recently. During cellular deformation, myosin II and cortexillin cooperatively accumulate in highly deformed region in response to the applied stress and the extent of accumulation increases with increased stress. The cooperativity is suggested to be mediated by the actin filaments. The accumulation of these proteins increases the mechanical resistance of the cells to against the external load, leading to a diminishing deformation.

Original languageEnglish (US)
Title of host publicationIFMBE Proceedings
Pages74-76
Number of pages3
Volume32 IFMBE
DOIs
StatePublished - 2010
Event26th Southern Biomedical Engineering Conference, SBEC 2010 - College Park, MD, United States
Duration: Apr 30 2010May 2 2010

Other

Other26th Southern Biomedical Engineering Conference, SBEC 2010
CountryUnited States
CityCollege Park, MD
Period4/30/105/2/10

Fingerprint

Myosin Type II
Actins
Proteins

Keywords

  • Actin
  • Actin cross-linking protein
  • Mechanosensing
  • Myosin

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

Cite this

Cooperative interactions between myosin II and cortexillin I mediated by actin filaments during cellular deformation. / Luo, Tianzhi; Robinson, Douglas.

IFMBE Proceedings. Vol. 32 IFMBE 2010. p. 74-76.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Luo, T & Robinson, D 2010, Cooperative interactions between myosin II and cortexillin I mediated by actin filaments during cellular deformation. in IFMBE Proceedings. vol. 32 IFMBE, pp. 74-76, 26th Southern Biomedical Engineering Conference, SBEC 2010, College Park, MD, United States, 4/30/10. https://doi.org/10.1007/978-3-642-14998-6_20
@inproceedings{42f9049909924e708e37dac2a815def5,
title = "Cooperative interactions between myosin II and cortexillin I mediated by actin filaments during cellular deformation",
abstract = "A mechanosensory system consisting non-muscle myosin II, cortexillin I, and actin filaments has been identified recently. During cellular deformation, myosin II and cortexillin cooperatively accumulate in highly deformed region in response to the applied stress and the extent of accumulation increases with increased stress. The cooperativity is suggested to be mediated by the actin filaments. The accumulation of these proteins increases the mechanical resistance of the cells to against the external load, leading to a diminishing deformation.",
keywords = "Actin, Actin cross-linking protein, Mechanosensing, Myosin",
author = "Tianzhi Luo and Douglas Robinson",
year = "2010",
doi = "10.1007/978-3-642-14998-6_20",
language = "English (US)",
isbn = "9783642149979",
volume = "32 IFMBE",
pages = "74--76",
booktitle = "IFMBE Proceedings",

}

TY - GEN

T1 - Cooperative interactions between myosin II and cortexillin I mediated by actin filaments during cellular deformation

AU - Luo, Tianzhi

AU - Robinson, Douglas

PY - 2010

Y1 - 2010

N2 - A mechanosensory system consisting non-muscle myosin II, cortexillin I, and actin filaments has been identified recently. During cellular deformation, myosin II and cortexillin cooperatively accumulate in highly deformed region in response to the applied stress and the extent of accumulation increases with increased stress. The cooperativity is suggested to be mediated by the actin filaments. The accumulation of these proteins increases the mechanical resistance of the cells to against the external load, leading to a diminishing deformation.

AB - A mechanosensory system consisting non-muscle myosin II, cortexillin I, and actin filaments has been identified recently. During cellular deformation, myosin II and cortexillin cooperatively accumulate in highly deformed region in response to the applied stress and the extent of accumulation increases with increased stress. The cooperativity is suggested to be mediated by the actin filaments. The accumulation of these proteins increases the mechanical resistance of the cells to against the external load, leading to a diminishing deformation.

KW - Actin

KW - Actin cross-linking protein

KW - Mechanosensing

KW - Myosin

UR - http://www.scopus.com/inward/record.url?scp=78049401995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78049401995&partnerID=8YFLogxK

U2 - 10.1007/978-3-642-14998-6_20

DO - 10.1007/978-3-642-14998-6_20

M3 - Conference contribution

AN - SCOPUS:78049401995

SN - 9783642149979

VL - 32 IFMBE

SP - 74

EP - 76

BT - IFMBE Proceedings

ER -