Convulsant-induced increase in transcription factor messenger RNAs in rat brain

D. W. Saffen, A. J. Cole, Paul F Worley, B. A. Christy, K. Ryder, Jay M Baraban

Research output: Contribution to journalArticle

Abstract

Administration of the convulsants pentylenetetrazole (Metrazole) or picrotoxin to rats caused a dramatic increase in mRNAs of four putative transcription factor genes, zif/268, c-jun, jun-B, and c-fos, in neurons of the hippocampus and dentate gyrus, as well as other areas of the cerebral cortex, including pyriform cortex and cingulate cortex. The increase in these mRNAs was rapid and transient: amounts peaked within 1 hr and returned to baseline within 2 hr. These results extend the observation made by Morgan et al. [Morgan, J.I., Cohen, D.R., Hempstead, J.L. & Curran, T. (1987) Science 237, 192-197] that c-fos mRNA and protein are induced in rat brain after seizures. We hypothesize that the increase of these putative transcription factor mRNAs in the brain is part of a programmed genomic response of neurons to intense stimulation, which is analogous to the genomic response of nonneuronal cells to growth factors.

Original languageEnglish (US)
Pages (from-to)7795-7799
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume85
Issue number20
StatePublished - 1988

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Convulsants
Transcription Factors
Messenger RNA
Pentylenetetrazole
Brain
Proto-Oncogene Proteins c-fos
Neurons
Picrotoxin
Gyrus Cinguli
Dentate Gyrus
Cerebral Cortex
Hippocampus
Intercellular Signaling Peptides and Proteins
Seizures
Observation
Genes

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Convulsant-induced increase in transcription factor messenger RNAs in rat brain. / Saffen, D. W.; Cole, A. J.; Worley, Paul F; Christy, B. A.; Ryder, K.; Baraban, Jay M.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, No. 20, 1988, p. 7795-7799.

Research output: Contribution to journalArticle

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