Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides

Hong Jun Song, Guo Li Ming, Zhigang He, Maxime Lehmann, Lisa McKerracher, Marc Tessier-Lavigne, Mu Ming Poo

Research output: Contribution to journalArticle

Abstract

Nerve growth is regulated by attractive and repulsive factors in the nervous system. Microscopic gradients of Collapsin-1/Semaphorin III/D (Sema III) and myelin-associated glycoprotein trigger repulsive turning responses by growth cones of cultured Xenopus spinal neurons; the repulsion can be converted to attraction by pharmacological activation of the guanosine 3',5'- monophosphate (cGMP) and adenosine 3',5'-monophosphate signaling pathways, respectively. Sema III also causes the collapse of cultured rat sensory growth cones, which can be inhibited by activation of the cGMP pathway. Thus cyclic nucleotides can regulate growth cone behaviors and may be targets for designing treatments to alleviate the inhibition of nerve regeneration by repulsive factors.

Original languageEnglish (US)
Pages (from-to)1515-1518
Number of pages4
JournalScience
Volume281
Issue number5382
DOIs
StatePublished - Sep 4 1998
Externally publishedYes

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    Song, H. J., Ming, G. L., He, Z., Lehmann, M., McKerracher, L., Tessier-Lavigne, M., & Poo, M. M. (1998). Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides. Science, 281(5382), 1515-1518. https://doi.org/10.1126/science.281.5382.1515