Conversion of hydrocortisone to estrogen in carcinoma of the breast after oophorectomy and adrenalectomy

G. L. Stonesifer, R. H. Lowe, J. L. Cameron, F. M. Ganis

Research output: Contribution to journalArticlepeer-review

Abstract

The data presented provide evidence that hydrocortisone can be converted to an 11 oxygenated estrogen since 11β hydroxyestradiol was identified in the urine of a female patient with mammary cancer who had undergone bilateral oophorectomy and adrenalectomy. It was noted that the identified 11β hydroxyestradiol was radioactive and therefore a metabolite of the labelled substrate 4 14C hydrocortisone that was administered. Retention of the 11 hydroxy function of the original substrate tends to support this conclusion. The identified conversion product represented approximately 5% of the radioactivity in the extracts, or approximately 0.7% of the total administered radioactivity. This finding demonstrates for the first time the direct conversion of hydrocortisone to an estrogen in such patients.

Original languageEnglish (US)
Pages (from-to)563-564
Number of pages2
JournalAnnals of surgery
Volume178
Issue number5
DOIs
StatePublished - 1973

ASJC Scopus subject areas

  • Surgery

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