The data presented provide evidence that hydrocortisone can be converted to an 11 oxygenated estrogen since 11β hydroxyestradiol was identified in the urine of a female patient with mammary cancer who had undergone bilateral oophorectomy and adrenalectomy. It was noted that the identified 11β hydroxyestradiol was radioactive and therefore a metabolite of the labelled substrate 4 14C hydrocortisone that was administered. Retention of the 11 hydroxy function of the original substrate tends to support this conclusion. The identified conversion product represented approximately 5% of the radioactivity in the extracts, or approximately 0.7% of the total administered radioactivity. This finding demonstrates for the first time the direct conversion of hydrocortisone to an estrogen in such patients.
ASJC Scopus subject areas