Conversion in off-pump coronary artery bypass grafting

An analysis of predictors and outcomes

James R. Edgerton, Todd M. Dewey, Mitchell J. Magee, Morley A. Herbert, Syma L. Prince, Katherine K. Jones, Michael J. Mack, Constantine Mavroudis, Bryan F. Meyers, Reza S. Khalafi, John M. Kratz

Research output: Contribution to journalArticle

Abstract

Background. The incidence, predictive factors, and outcomes related to conversion from off-pump coronary artery bypass (OPCAB) to on-pump coronary artery bypass grafting (ONCAB) have not been well defined. We sought to determine the incidence of conversion, predictive factors, and any associated adverse consequences. Methods. From January 2000 through June 2002, 1,644 patients underwent nonemergent OPCAB with 61 patients requiring conversion from OPCAB to ONCAB. These groups were retrospectively compared by univariate and multivariate regression analysis. The converted group was then computer matched 1:3, to a cohort of ONCAB patients to determine differences in outcomes. Results. The overall conversion rate was 3.71%. Converted patients compared with a computer-matched ONCAB patients had a higher incidence of operative mortality (18.0% versus 2.7%, p < 0.001). Urgently converted patients had a higher incidence of postoperative cardiac arrest (25% versus 1.1%, p < 0.001), multisystem organ failure (10.7% versus 0.6%, p < 0.001), vascular complications (7.1% versus 1.1%, p = 0.03), and perioperative myocardial infarction (10.7% versus 1.1%, p = 0.02). Predictive factors for conversion were surgeon early in OPCAB experience (odds ratio [OR] 4.4), previous CABG (OR 2.8), and congestive heart failure (OR 2.0). The need for urgent-emergent conversion was highly predictive for operative mortality (OR 7.3) compared with elective conversion. Conclusions. Patients undergoing urgent-emergent but not elective conversion from OPCAB to ONCAB had a significantly higher risk of mortality and morbidity compared with patients whose procedure was initially ONCAB. Variables predictive of conversion included previous CABG, congestive heart failure, and surgeons early in OPCAB experience.

Original languageEnglish (US)
Pages (from-to)1138-1143
Number of pages6
JournalAnnals of Thoracic Surgery
Volume76
Issue number4
DOIs
StatePublished - Oct 1 2003
Externally publishedYes

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Off-Pump Coronary Artery Bypass
Coronary Artery Bypass
Odds Ratio
Incidence
Mortality
Heart Failure
Heart Arrest
Blood Vessels
Multivariate Analysis
Myocardial Infarction
Regression Analysis
Morbidity

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Edgerton, J. R., Dewey, T. M., Magee, M. J., Herbert, M. A., Prince, S. L., Jones, K. K., ... Kratz, J. M. (2003). Conversion in off-pump coronary artery bypass grafting: An analysis of predictors and outcomes. Annals of Thoracic Surgery, 76(4), 1138-1143. https://doi.org/10.1016/S0003-4975(03)00747-1

Conversion in off-pump coronary artery bypass grafting : An analysis of predictors and outcomes. / Edgerton, James R.; Dewey, Todd M.; Magee, Mitchell J.; Herbert, Morley A.; Prince, Syma L.; Jones, Katherine K.; Mack, Michael J.; Mavroudis, Constantine; Meyers, Bryan F.; Khalafi, Reza S.; Kratz, John M.

In: Annals of Thoracic Surgery, Vol. 76, No. 4, 01.10.2003, p. 1138-1143.

Research output: Contribution to journalArticle

Edgerton, JR, Dewey, TM, Magee, MJ, Herbert, MA, Prince, SL, Jones, KK, Mack, MJ, Mavroudis, C, Meyers, BF, Khalafi, RS & Kratz, JM 2003, 'Conversion in off-pump coronary artery bypass grafting: An analysis of predictors and outcomes', Annals of Thoracic Surgery, vol. 76, no. 4, pp. 1138-1143. https://doi.org/10.1016/S0003-4975(03)00747-1
Edgerton, James R. ; Dewey, Todd M. ; Magee, Mitchell J. ; Herbert, Morley A. ; Prince, Syma L. ; Jones, Katherine K. ; Mack, Michael J. ; Mavroudis, Constantine ; Meyers, Bryan F. ; Khalafi, Reza S. ; Kratz, John M. / Conversion in off-pump coronary artery bypass grafting : An analysis of predictors and outcomes. In: Annals of Thoracic Surgery. 2003 ; Vol. 76, No. 4. pp. 1138-1143.
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abstract = "Background. The incidence, predictive factors, and outcomes related to conversion from off-pump coronary artery bypass (OPCAB) to on-pump coronary artery bypass grafting (ONCAB) have not been well defined. We sought to determine the incidence of conversion, predictive factors, and any associated adverse consequences. Methods. From January 2000 through June 2002, 1,644 patients underwent nonemergent OPCAB with 61 patients requiring conversion from OPCAB to ONCAB. These groups were retrospectively compared by univariate and multivariate regression analysis. The converted group was then computer matched 1:3, to a cohort of ONCAB patients to determine differences in outcomes. Results. The overall conversion rate was 3.71{\%}. Converted patients compared with a computer-matched ONCAB patients had a higher incidence of operative mortality (18.0{\%} versus 2.7{\%}, p < 0.001). Urgently converted patients had a higher incidence of postoperative cardiac arrest (25{\%} versus 1.1{\%}, p < 0.001), multisystem organ failure (10.7{\%} versus 0.6{\%}, p < 0.001), vascular complications (7.1{\%} versus 1.1{\%}, p = 0.03), and perioperative myocardial infarction (10.7{\%} versus 1.1{\%}, p = 0.02). Predictive factors for conversion were surgeon early in OPCAB experience (odds ratio [OR] 4.4), previous CABG (OR 2.8), and congestive heart failure (OR 2.0). The need for urgent-emergent conversion was highly predictive for operative mortality (OR 7.3) compared with elective conversion. Conclusions. Patients undergoing urgent-emergent but not elective conversion from OPCAB to ONCAB had a significantly higher risk of mortality and morbidity compared with patients whose procedure was initially ONCAB. Variables predictive of conversion included previous CABG, congestive heart failure, and surgeons early in OPCAB experience.",
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T1 - Conversion in off-pump coronary artery bypass grafting

T2 - An analysis of predictors and outcomes

AU - Edgerton, James R.

AU - Dewey, Todd M.

AU - Magee, Mitchell J.

AU - Herbert, Morley A.

AU - Prince, Syma L.

AU - Jones, Katherine K.

AU - Mack, Michael J.

AU - Mavroudis, Constantine

AU - Meyers, Bryan F.

AU - Khalafi, Reza S.

AU - Kratz, John M.

PY - 2003/10/1

Y1 - 2003/10/1

N2 - Background. The incidence, predictive factors, and outcomes related to conversion from off-pump coronary artery bypass (OPCAB) to on-pump coronary artery bypass grafting (ONCAB) have not been well defined. We sought to determine the incidence of conversion, predictive factors, and any associated adverse consequences. Methods. From January 2000 through June 2002, 1,644 patients underwent nonemergent OPCAB with 61 patients requiring conversion from OPCAB to ONCAB. These groups were retrospectively compared by univariate and multivariate regression analysis. The converted group was then computer matched 1:3, to a cohort of ONCAB patients to determine differences in outcomes. Results. The overall conversion rate was 3.71%. Converted patients compared with a computer-matched ONCAB patients had a higher incidence of operative mortality (18.0% versus 2.7%, p < 0.001). Urgently converted patients had a higher incidence of postoperative cardiac arrest (25% versus 1.1%, p < 0.001), multisystem organ failure (10.7% versus 0.6%, p < 0.001), vascular complications (7.1% versus 1.1%, p = 0.03), and perioperative myocardial infarction (10.7% versus 1.1%, p = 0.02). Predictive factors for conversion were surgeon early in OPCAB experience (odds ratio [OR] 4.4), previous CABG (OR 2.8), and congestive heart failure (OR 2.0). The need for urgent-emergent conversion was highly predictive for operative mortality (OR 7.3) compared with elective conversion. Conclusions. Patients undergoing urgent-emergent but not elective conversion from OPCAB to ONCAB had a significantly higher risk of mortality and morbidity compared with patients whose procedure was initially ONCAB. Variables predictive of conversion included previous CABG, congestive heart failure, and surgeons early in OPCAB experience.

AB - Background. The incidence, predictive factors, and outcomes related to conversion from off-pump coronary artery bypass (OPCAB) to on-pump coronary artery bypass grafting (ONCAB) have not been well defined. We sought to determine the incidence of conversion, predictive factors, and any associated adverse consequences. Methods. From January 2000 through June 2002, 1,644 patients underwent nonemergent OPCAB with 61 patients requiring conversion from OPCAB to ONCAB. These groups were retrospectively compared by univariate and multivariate regression analysis. The converted group was then computer matched 1:3, to a cohort of ONCAB patients to determine differences in outcomes. Results. The overall conversion rate was 3.71%. Converted patients compared with a computer-matched ONCAB patients had a higher incidence of operative mortality (18.0% versus 2.7%, p < 0.001). Urgently converted patients had a higher incidence of postoperative cardiac arrest (25% versus 1.1%, p < 0.001), multisystem organ failure (10.7% versus 0.6%, p < 0.001), vascular complications (7.1% versus 1.1%, p = 0.03), and perioperative myocardial infarction (10.7% versus 1.1%, p = 0.02). Predictive factors for conversion were surgeon early in OPCAB experience (odds ratio [OR] 4.4), previous CABG (OR 2.8), and congestive heart failure (OR 2.0). The need for urgent-emergent conversion was highly predictive for operative mortality (OR 7.3) compared with elective conversion. Conclusions. Patients undergoing urgent-emergent but not elective conversion from OPCAB to ONCAB had a significantly higher risk of mortality and morbidity compared with patients whose procedure was initially ONCAB. Variables predictive of conversion included previous CABG, congestive heart failure, and surgeons early in OPCAB experience.

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