Conversion Chemotherapy for Unresectable Colorectal Liver Metastases: Are We Making a Difference?

Ali Mokdad, Michael A. Choti, Adam C. Yopp

Research output: Contribution to journalReview article

Abstract

Surgical resection remains the only curative therapy for colorectal liver metastases (CLM) with 5-year survival rates ranging from 40 to 58 %. Unfortunately, only approximately 15–25 % of patients are eligible for initial surgical resection. Among those that are unresectable, response to chemotherapy can convert an additional 15–20 % of unresectable patients to a potentially resectable state and offer curative-intent resection. In this select group of patients undergoing resection following conversion chemotherapy, 5-year survival rates approach 50 %. Despite a slightly shorter time to recurrence post-hepatectomy following conversion chemotherapy, these select patients have a significant survival advantage compared to palliative chemotherapy alone.

Original languageEnglish (US)
Pages (from-to)160-167
Number of pages8
JournalCurrent Colorectal Cancer Reports
Volume11
Issue number4
DOIs
StatePublished - Aug 3 2015

Keywords

  • Colorectal carcinoma
  • Colorectal liver metastases
  • Hepatic resection
  • Systemic chemotherapy

ASJC Scopus subject areas

  • Hepatology
  • Oncology
  • Gastroenterology

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