Converging roles for sphingolipids and cell stress in the progression of neuro-AIDS

Norman Haughey, Joesph Steiner, Avindra Nath, Justin Charles McArthur, Ned Sacktor, Carlos A Pardo-Villamizar, Veera Venkata, Ratnam Bandaru

Research output: Contribution to journalArticle

Abstract

Sphingolipids are a class of lipids enriched in the central nervous system that have important roles in signal transduction. Recent advances in our understanding of how sphingolipids are involved in the control of life and death signaling have uncovered roles for these lipids in the neuropathogenesis of HIV-associated neurocognitive disorders (HAND). In this review we briefly summarize the molecular mechanisms involved in the pathological production of the toxic sphingolipid, ceramide and address questions of how cytokine and cellular stress pathways that are perturbed in HAND converge to deregulate ceramide-associated signaling.

Original languageEnglish (US)
Pages (from-to)5120-5130
Number of pages11
JournalFrontiers in bioscience : a journal and virtual library
Volume13
Issue number13
DOIs
StatePublished - 2008

Fingerprint

Sphingolipids
Acquired Immunodeficiency Syndrome
Ceramides
HIV
Lipids
Signal transduction
Poisons
Neurology
Signal Transduction
Central Nervous System
Cytokines
Neurocognitive Disorders

Keywords

  • Ceramide
  • Cytokines
  • Dementia
  • FAS
  • HAND
  • HIV
  • IL1
  • Oxidative stress
  • Sphingomyelin
  • Sphingomyelinase
  • TNF

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Converging roles for sphingolipids and cell stress in the progression of neuro-AIDS. / Haughey, Norman; Steiner, Joesph; Nath, Avindra; McArthur, Justin Charles; Sacktor, Ned; Pardo-Villamizar, Carlos A; Venkata, Veera; Bandaru, Ratnam.

In: Frontiers in bioscience : a journal and virtual library, Vol. 13, No. 13, 2008, p. 5120-5130.

Research output: Contribution to journalArticle

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