Converging roles for sphingolipids and cell stress in the progression of neuro-AIDS

Norman J. Haughey, Joesph Steiner, Avindra Nath, Justin C. McArthur, Ned Sacktor, Carlos Pardo, Veera Venkata, Ratnam Bandaru

Research output: Contribution to journalReview article

Abstract

Sphingolipids are a class of lipids enriched in the central nervous system that have important roles in signal transduction. Recent advances in our understanding of how sphingolipids are involved in the control of life and death signaling have uncovered roles for these lipids in the neuropathogenesis of HIV-associated neurocognitive disorders (HAND). In this review we briefly summarize the molecular mechanisms involved in the pathological production of the toxic sphingolipid, ceramide and address questions of how cytokine and cellular stress pathways that are perturbed in HAND converge to deregulate ceramide-associated signaling.

Original languageEnglish (US)
Pages (from-to)5120-5130
Number of pages11
JournalFrontiers in Bioscience
Volume13
Issue number13
DOIs
StatePublished - May 5 2008

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Keywords

  • Ceramide
  • Cytokines
  • Dementia
  • FAS
  • HAND
  • HIV
  • IL1
  • Oxidative stress
  • Sphingomyelin
  • Sphingomyelinase
  • TNF

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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