Converging models of schizophrenia - Network alterations of prefrontal cortex underlying cognitive impairments

Takeshi Sakurai, Nao J. Gamo, Takatoshi Hikida, Sun Hong Kim, Toshiya Murai, Toshifumi Tomoda, Akira Sawa

Research output: Contribution to journalReview articlepeer-review


The prefrontal cortex (PFC) and its connections with other brain areas are crucial for cognitive function. Cognitive impairments are one of the core symptoms associated with schizophrenia, and manifest even before the onset of the disorder. Altered neural networks involving PFC contribute to cognitive impairments in schizophrenia. Both genetic and environmental risk factors affect the development of the local circuitry within PFC as well as development of broader brain networks, and make the system vulnerable to further insults during adolescence, leading to the onset of the disorder in young adulthood. Since spared cognitive functions correlate with functional outcome and prognosis, a better understanding of the mechanisms underlying cognitive impairments will have important implications for novel therapeutics for schizophrenia focusing on cognitive functions. Multidisciplinary approaches, from basic neuroscience to clinical studies, are required to link molecules, circuitry, networks, and behavioral phenotypes. Close interactions among such fields by sharing a common language on connectomes, behavioral readouts, and other concepts are crucial for this goal.

Original languageEnglish (US)
Pages (from-to)178-201
Number of pages24
JournalProgress in Neurobiology
StatePublished - Nov 1 2015


  • Brain imaging
  • Circuitry formation
  • Circuitry maturation
  • Cognitive function
  • Networks
  • Oscillation
  • Prefrontal cortex

ASJC Scopus subject areas

  • Neuroscience(all)


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