Conventional magnetic resonance imaging features in patients with tropical spastic paraparesis

Francesca Bagnato, John Butman, Carlos A. Mora, Shiva Gupta, Yoshima Yamano, Talin A. Tasciyan, Jeffrey M. Solomon, Waldyr J. Santos, Roger D. Stone, Henry F. McFarland, Steven Jacobson

Research output: Contribution to journalArticle

Abstract

Conventional brain and spinal cord magnetic resonance images were performed in 21 patients with human T-cell lymphotropic virus (HTLV)-1 associated myelopathy/tropical spastic paraparesis, to assess the role of conventional magnetic resonance imaging (MRI) in the disease diagnosis. These patients had no other central nervous system conditions or related risk factors at the time of tropical spastic paraparesis diagnosis. Eleven (52.4%) patients showed nonspecific brain abnormalities on T2-weighted images. The majority (77.2%) of brain abnormalities were located in the deep white matter. A transient contrast-enhancing lesion was identified in the brain of only one patient. In the brain of another patient, 9.0% of the T2-hyperintense lesion load was hypointense on the correspondent T1-weighted images. No differences in terms of demographic, biological, or clinical variables were present between patients with abnormal brain images and those with normal brain magnetic resonance images. Spinal cord T2-weighted images were abnormal in three (14.3%) patients. In one of these three patients, a diffuse but transient edema was found along the entire tract of the spinal cord. White matter lesions were present in the central nervous system of 60% of the cases in this study. However, no correlations between magnetic resonance imaging and clinical findings, and no specificity of lesions were observed. Hence, conventional magnetic resonance imaging is a sensitive but not highly specific tool for diagnosis of tropical spastic paraparesis.

Original languageEnglish (US)
Pages (from-to)525-534
Number of pages10
JournalJournal of NeuroVirology
Volume11
Issue number6
DOIs
StatePublished - Dec 1 2005
Externally publishedYes

Fingerprint

Tropical Spastic Paraparesis
Magnetic Resonance Imaging
Brain
Spinal Cord
Magnetic Resonance Spectroscopy
Central Nervous System
Human T-lymphotropic virus 1
Spinal Cord Diseases
Edema
Demography
T-Lymphocytes

Keywords

  • Brain
  • Disability
  • HTLV-1
  • Magnetic resonance imaging
  • Spinal cord
  • Tropical spastic paraparesis

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology

Cite this

Bagnato, F., Butman, J., Mora, C. A., Gupta, S., Yamano, Y., Tasciyan, T. A., ... Jacobson, S. (2005). Conventional magnetic resonance imaging features in patients with tropical spastic paraparesis. Journal of NeuroVirology, 11(6), 525-534. https://doi.org/10.1080/13550280500385039

Conventional magnetic resonance imaging features in patients with tropical spastic paraparesis. / Bagnato, Francesca; Butman, John; Mora, Carlos A.; Gupta, Shiva; Yamano, Yoshima; Tasciyan, Talin A.; Solomon, Jeffrey M.; Santos, Waldyr J.; Stone, Roger D.; McFarland, Henry F.; Jacobson, Steven.

In: Journal of NeuroVirology, Vol. 11, No. 6, 01.12.2005, p. 525-534.

Research output: Contribution to journalArticle

Bagnato, F, Butman, J, Mora, CA, Gupta, S, Yamano, Y, Tasciyan, TA, Solomon, JM, Santos, WJ, Stone, RD, McFarland, HF & Jacobson, S 2005, 'Conventional magnetic resonance imaging features in patients with tropical spastic paraparesis', Journal of NeuroVirology, vol. 11, no. 6, pp. 525-534. https://doi.org/10.1080/13550280500385039
Bagnato, Francesca ; Butman, John ; Mora, Carlos A. ; Gupta, Shiva ; Yamano, Yoshima ; Tasciyan, Talin A. ; Solomon, Jeffrey M. ; Santos, Waldyr J. ; Stone, Roger D. ; McFarland, Henry F. ; Jacobson, Steven. / Conventional magnetic resonance imaging features in patients with tropical spastic paraparesis. In: Journal of NeuroVirology. 2005 ; Vol. 11, No. 6. pp. 525-534.
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