Controlling plasma stimulated media in cancer treatment application

Dayun Yan, Jonathan H. Sherman, Xiaoqian Cheng, Edward Ratovitski, Jerome Canady, Michael Keidar

Research output: Contribution to journalArticlepeer-review

Abstract

Cold atmospheric plasma (CAP) constitutes a "cocktail" of various reactive species. Accumulating evidence shows the effectiveness of CAP in killing cancer cells and decreasing the tumor size, which provides a solid basis for its potential use in cancer treatment. Currently, CAP is mainly used to directly treat cancer cells and trigger the death of cancer cells via apoptosis or necrosis. By altering the concentration of fetal bovine serum in Dulbecco's modified Eagle's medium and the temperature to store CAP stimulated media, we demonstrated controllable strategies to harness the stimulated media to kill glioblastoma cells in vitro. This study demonstrated the significant role of media in killing cancer cells via the CAP treatment.

Original languageEnglish (US)
Article number224101
JournalApplied Physics Letters
Volume105
Issue number22
DOIs
StatePublished - Dec 1 2014

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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