Controlling plasma stimulated media in cancer treatment application

Dayun Yan; Jonathan H. Sherman; Xiaoqian Cheng; Edward Ratovitski; Jerome Canady; Michael Keidar

doi:10.1063/1.4902875

Controlling plasma stimulated media in cancer treatment application

Dayun Yan, Jonathan H. Sherman, Xiaoqian Cheng, Edward Ratovitski, Jerome Canady, Michael Keidar

School of Medicine

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Cold atmospheric plasma (CAP) constitutes a "cocktail" of various reactive species. Accumulating evidence shows the effectiveness of CAP in killing cancer cells and decreasing the tumor size, which provides a solid basis for its potential use in cancer treatment. Currently, CAP is mainly used to directly treat cancer cells and trigger the death of cancer cells via apoptosis or necrosis. By altering the concentration of fetal bovine serum in Dulbecco's modified Eagle's medium and the temperature to store CAP stimulated media, we demonstrated controllable strategies to harness the stimulated media to kill glioblastoma cells in vitro. This study demonstrated the significant role of media in killing cancer cells via the CAP treatment.

Original language	English (US)
Article number	224101
Journal	Applied Physics Letters
Volume	105
Issue number	22
DOIs	https://doi.org/10.1063/1.4902875
State	Published - Dec 1 2014

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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10.1063/1.4902875

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AU - Sherman, Jonathan H.

AU - Cheng, Xiaoqian

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AU - Canady, Jerome

AU - Keidar, Michael

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AB - Cold atmospheric plasma (CAP) constitutes a "cocktail" of various reactive species. Accumulating evidence shows the effectiveness of CAP in killing cancer cells and decreasing the tumor size, which provides a solid basis for its potential use in cancer treatment. Currently, CAP is mainly used to directly treat cancer cells and trigger the death of cancer cells via apoptosis or necrosis. By altering the concentration of fetal bovine serum in Dulbecco's modified Eagle's medium and the temperature to store CAP stimulated media, we demonstrated controllable strategies to harness the stimulated media to kill glioblastoma cells in vitro. This study demonstrated the significant role of media in killing cancer cells via the CAP treatment.

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Controlling plasma stimulated media in cancer treatment application

Abstract

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