Abstract
Two new methods for insertional mutagenesis in Drosophila are now available. They are based on the ability to control experimentally the number of stable P element insertions per mutagenized strain. One method produces about 10 insertions per genome and has the potential to replace hybrid dysgenesis as a means for cloning genes by transposon tagging. The other mobilizes elements less frequently, producing strains containing a single P element that can be correlated with any resulting mutant phenotype. A library of single-element strains is currently being assembled and will be a valuable resource for Drosophila molecular genetics.
Original language | English (US) |
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Pages (from-to) | 254-258 |
Number of pages | 5 |
Journal | Trends in Genetics |
Volume | 4 |
Issue number | 9 |
DOIs | |
State | Published - 1988 |
Externally published | Yes |
ASJC Scopus subject areas
- Genetics