Controlled trial of continuous negative external pressure in the treatment of severe respiratory distress syndrome

Avroy A. Fanaroff, Chul Choon Cha, Roberto Sosa, Robert S. Crumrine, Marshall H. Klaus

Research output: Contribution to journalArticlepeer-review

Abstract

A sequential controlled trial of continuous negative pressure versus oxygen in treatment of severe respiratory distress syndrome (PaO2<60 mm. Hg in FiO2 70 per cent or greater) was performed. CNP was applied by means of a newly designed, inexpensive plastic chamber. Twenty-nine infants with RDS who weighed >1,000 Gm. and who had no congenital malformations were studied; there were 14 in the oxygen-treated control group and 15 in the CNP-treated group. Following the study, seven additional infants were treated with CNP. Birth weights, sex, gestational ages, ages, and blood gases at the time of admission to the study were similar. Study failure was defined as a PaO2<50 mm. Hg in 100 per cent oxygen, or onset of apnea. Sequential analysis revealed CNP was superior to oxygen (p<0.05): study successes-CNP group, 10 of 15 (67 per cent) and oxygen-treated control group, 2 of 14 (14 per cent). CNP improves oxygenation in RDS and significantly reduces duration of exposure to high oxygen concentration and the need for respirator therapy. The over-all survival rate was 72 per cent.

Original languageEnglish (US)
Pages (from-to)921-928
Number of pages8
JournalThe Journal of pediatrics
Volume82
Issue number6
DOIs
StatePublished - Jun 1973
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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