Controlled trial of chlorpromazine as antisecretory agent in patients with cholera hydrated intravenously

G. H. Rabbani, W. B. Greenough, J. Holmgren, B. Kirkwood

Research output: Contribution to journalArticle

Abstract

A randomised controlled trial was conducted to investigate the ability of chlorpromazine to reduce intestinal secretion in cholera. Chlorpromazine had reduced loss of intestinal fluid in animals with diarrhoea induced by cholera toxin, and in a preliminary study the drug had reduced purging in patients with cholera. Forty-six adults with cholera were included in the randomised trial. Of these, 34 were treated with chlorpromazine (1 mg/kg or 4 mg/kg either by mouth or intramuscularly) and 12 served as controls. After treatment with the drug there was a significantly greater reduction in the rate of fluid loss in the treated patients than in the controls during the first (p < 0.005), second (p < 0.05), and fourth (p < 0.01) eight-hour periods but not during the third eight-hour period; the dose of 4 mg/kg was only marginally more effective than 1 mg/kg. The effect of chlorpromazine was strikingly biphasic, with one peak during the first eight hours and another 24-32 hours after administration. Chlorpromazine also significantly reduced the duration of diarrhoea, frequency of vomiting, and amount of intravenous fluid required. The drug induced mild sedation and no hypotension in these well-hydrated patients.

Original languageEnglish (US)
Pages (from-to)1361-1364
Number of pages4
JournalBritish medical journal
Volume284
Issue number6326
StatePublished - Jan 1 1982

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ASJC Scopus subject areas

  • Medicine(all)

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