TY - GEN
T1 - Controlled release polymers to deliver drugs to the brain
AU - Brem, Henry
PY - 1992/12/1
Y1 - 1992/12/1
N2 - We have developed a polymeric system for delivering high concentrations of drugs over a sustained period of time directly to the brain. The development of poly[bis(p-carboxyphenoxy)propane-sebacic acid] (PCPP-SA) has a number of advantages for use in the brain. We have carried out a number of experiments to demonstrate the biocompatibility of the PCPP-SA, the drug distribution of a themotherapeutic agent from the polymer implanted in the brain, and the intracranial efficacy of BCNU PCPP-SA against brain tumor implants. We concluded that, based on these laboratory studies: (1) PCPP-SA was biocompatible and could be implanted safely in the brains of redents and primates; (2) BCNU incorporated into PCPP-SA could be released in a sustained controlled fashion; and (3) delivery of BCNU in this fashion could effectively inhibit the growth of an experimental malignant glioms in a manner superior to the standard systemic administration of BCNU.
AB - We have developed a polymeric system for delivering high concentrations of drugs over a sustained period of time directly to the brain. The development of poly[bis(p-carboxyphenoxy)propane-sebacic acid] (PCPP-SA) has a number of advantages for use in the brain. We have carried out a number of experiments to demonstrate the biocompatibility of the PCPP-SA, the drug distribution of a themotherapeutic agent from the polymer implanted in the brain, and the intracranial efficacy of BCNU PCPP-SA against brain tumor implants. We concluded that, based on these laboratory studies: (1) PCPP-SA was biocompatible and could be implanted safely in the brains of redents and primates; (2) BCNU incorporated into PCPP-SA could be released in a sustained controlled fashion; and (3) delivery of BCNU in this fashion could effectively inhibit the growth of an experimental malignant glioms in a manner superior to the standard systemic administration of BCNU.
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M3 - Conference contribution
AN - SCOPUS:0026986795
SN - 0841222169
T3 - Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering
SP - 85
EP - 86
BT - Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering
PB - Publ by ACS
ER -