Controlled release polymers to deliver drugs to the brain

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have developed a polymeric system for delivering high concentrations of drugs over a sustained period of time directly to the brain. The development of poly[bis(p-carboxyphenoxy)propane-sebacic acid] (PCPP-SA) has a number of advantages for use in the brain. We have carried out a number of experiments to demonstrate the biocompatibility of the PCPP-SA, the drug distribution of a themotherapeutic agent from the polymer implanted in the brain, and the intracranial efficacy of BCNU PCPP-SA against brain tumor implants. We concluded that, based on these laboratory studies: (1) PCPP-SA was biocompatible and could be implanted safely in the brains of redents and primates; (2) BCNU incorporated into PCPP-SA could be released in a sustained controlled fashion; and (3) delivery of BCNU in this fashion could effectively inhibit the growth of an experimental malignant glioms in a manner superior to the standard systemic administration of BCNU.

Original languageEnglish (US)
Title of host publicationPolymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering
PublisherPubl by ACS
Pages85-86
Number of pages2
Volume66
ISBN (Print)0841222169
StatePublished - 1992

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Propane
Carmustine
Brain
Polymers
Acids
Pharmaceutical Preparations
Biocompatibility
Tumors
sebacic acid
Experiments

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Polymers and Plastics

Cite this

Brem, H. (1992). Controlled release polymers to deliver drugs to the brain. In Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering (Vol. 66, pp. 85-86). Publ by ACS.

Controlled release polymers to deliver drugs to the brain. / Brem, Henry.

Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering. Vol. 66 Publ by ACS, 1992. p. 85-86.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Brem, H 1992, Controlled release polymers to deliver drugs to the brain. in Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering. vol. 66, Publ by ACS, pp. 85-86.
Brem H. Controlled release polymers to deliver drugs to the brain. In Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering. Vol. 66. Publ by ACS. 1992. p. 85-86
Brem, Henry. / Controlled release polymers to deliver drugs to the brain. Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering. Vol. 66 Publ by ACS, 1992. pp. 85-86
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