Controlled release for immunotherapy: Analysis of intracranial transport of IL-2

S. Kalyanasundaram, Z. Zhao, A. Sills, H. Brem, K. W. Leong

Research output: Contribution to journalArticle

Abstract

A mathematical analysis of the transport of IL-2 released in a controlled manner in the brain, predicts that at early time points following implantation, convective flow augmented by the presence of edema is the major determinant of transport. The anatomical complexities of the brain play an important role in determining the fate of the IL-2 molecules. These effects cannot be predicted by a simple one dimensional analysis of the transport. Comparison of this model with experimental results will be presented.

Original languageEnglish (US)
Pages (from-to)119-120
Number of pages2
JournalProceedings of the Controlled Release Society
Issue number23
StatePublished - 1996

ASJC Scopus subject areas

  • Pharmaceutical Science

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