TY - JOUR
T1 - Controlled clinical trials in emergency medicine
AU - Brown, Charles G.
AU - Moser, Michael
AU - Moeschberger, Melvin
AU - Kelen, Gabor D.
PY - 1985/1
Y1 - 1985/1
N2 - In this first article of a series on controlled clinical trials in emergency medicine, an overview of the structure of such studies and the relevant issues related to study design, data generation, statistical analysis, and reporting are presented. The importance of precise patient selection, randomization and stratification, blinding, and equivalent therapeutic intervention in study design has been discussed. In addition, precise outcome and measurement criteria, assessor qualifications, deficiencies in data, appropriate sample-size selection, and reporting are also presented. Although an idealized framework for the conduct and analysis of a controlled clinical trial is provided, it should be appreciated that design and analytical compromises may at times be difficult to avoid in clinical research. Future articles in this series will discuss randomization in clinical trials, alternatives to randomization, beta error and sample-size determination, the statistical and analytical issues related to imperfections in the execution of a trial, and issues related to the reporting of clinical trials.
AB - In this first article of a series on controlled clinical trials in emergency medicine, an overview of the structure of such studies and the relevant issues related to study design, data generation, statistical analysis, and reporting are presented. The importance of precise patient selection, randomization and stratification, blinding, and equivalent therapeutic intervention in study design has been discussed. In addition, precise outcome and measurement criteria, assessor qualifications, deficiencies in data, appropriate sample-size selection, and reporting are also presented. Although an idealized framework for the conduct and analysis of a controlled clinical trial is provided, it should be appreciated that design and analytical compromises may at times be difficult to avoid in clinical research. Future articles in this series will discuss randomization in clinical trials, alternatives to randomization, beta error and sample-size determination, the statistical and analytical issues related to imperfections in the execution of a trial, and issues related to the reporting of clinical trials.
KW - Controlled clinical trials
KW - research design
KW - research methodology
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U2 - 10.1016/0735-6757(85)90016-6
DO - 10.1016/0735-6757(85)90016-6
M3 - Article
C2 - 3970757
AN - SCOPUS:0021968533
SN - 0735-6757
VL - 3
SP - 67
EP - 73
JO - American Journal of Emergency Medicine
JF - American Journal of Emergency Medicine
IS - 1
ER -