Controlled clinical trials in emergency medicine

Charles G. Brown, Michael Moser, Melvin Moeschberger, Gabor D. Kelen

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


In this first article of a series on controlled clinical trials in emergency medicine, an overview of the structure of such studies and the relevant issues related to study design, data generation, statistical analysis, and reporting are presented. The importance of precise patient selection, randomization and stratification, blinding, and equivalent therapeutic intervention in study design has been discussed. In addition, precise outcome and measurement criteria, assessor qualifications, deficiencies in data, appropriate sample-size selection, and reporting are also presented. Although an idealized framework for the conduct and analysis of a controlled clinical trial is provided, it should be appreciated that design and analytical compromises may at times be difficult to avoid in clinical research. Future articles in this series will discuss randomization in clinical trials, alternatives to randomization, beta error and sample-size determination, the statistical and analytical issues related to imperfections in the execution of a trial, and issues related to the reporting of clinical trials.

Original languageEnglish (US)
Pages (from-to)67-73
Number of pages7
JournalAmerican Journal of Emergency Medicine
Issue number1
StatePublished - Jan 1985


  • Controlled clinical trials
  • research design
  • research methodology

ASJC Scopus subject areas

  • Emergency Medicine


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