Control of total systemic vascular capacity by the carotid sinus baroreceptor reflex

Artin A Shoukas, K. Sagawa

Research output: Contribution to journalArticle

Abstract

To attain a quantitative understanding of carotid sinus baroreceptor reflex control of cardiac output the authors studied the reflex control of total systemic vascular capacity in vagotomized dogs. In experiments measuring blood volume shifts caused by the carotid sinus reflex (series 1), venous return was diverted into a reservoir while cardiac output and central venous pressure were maintained at constant levels. The pressure in the isolated carotid sinuses (ISP) was lowered or raised in 25 mm Hg steps between 75 and 200 mm Hg. This procedure mobilized blood into or out of the reservoir, indicating a decrease or an increase in total vascular capacity, respectively. The mean maximum volume shift, 3.6 ml/kg body weight, occurred in the same ISP region, 135±12.5 mm Hg, where reflex control of total peripheral resistance was strongest. The total volume shift was approximately 7.5 ml/kg for ISP changes from 75 to 200 mm Hg. When mean arterial blood pressure was maintained constant during the ISP step changes, the volume shift almost doubled. In experiments measuring the reflex effect on total systemic vascular compliance (series 2) and in experiments determining the reflex control of arterial complicance (series 3), total systemic vascular and lumped arterial compliances were measured in the same dogs that were used in series 1 experiments. The total systemic vascular and arterial compliances were approximately 2.0 ml/mm Hg kg-1 and 0.0677 ml/mm Hg kg-1, respectively. The reflex did not affect these compliances. The authors concluded that the reflex controls the total systemic venous capacity to a degree that changes output potentially by 30-40% per 25 mm Hg change in ISP.

Original languageEnglish (US)
Pages (from-to)22-33
Number of pages12
JournalCirculation Research
Volume33
Issue number1
StatePublished - 1973

Fingerprint

Carotid Sinus
Baroreflex
Blood Vessels
Reflex
Compliance
Cardiac Output
Arterial Pressure
Dogs
Central Venous Pressure
Blood Volume
Vascular Resistance
Body Weight
Pressure

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Control of total systemic vascular capacity by the carotid sinus baroreceptor reflex. / Shoukas, Artin A; Sagawa, K.

In: Circulation Research, Vol. 33, No. 1, 1973, p. 22-33.

Research output: Contribution to journalArticle

@article{d73ac86054eb4c21b961cb2ca0ce55b4,
title = "Control of total systemic vascular capacity by the carotid sinus baroreceptor reflex",
abstract = "To attain a quantitative understanding of carotid sinus baroreceptor reflex control of cardiac output the authors studied the reflex control of total systemic vascular capacity in vagotomized dogs. In experiments measuring blood volume shifts caused by the carotid sinus reflex (series 1), venous return was diverted into a reservoir while cardiac output and central venous pressure were maintained at constant levels. The pressure in the isolated carotid sinuses (ISP) was lowered or raised in 25 mm Hg steps between 75 and 200 mm Hg. This procedure mobilized blood into or out of the reservoir, indicating a decrease or an increase in total vascular capacity, respectively. The mean maximum volume shift, 3.6 ml/kg body weight, occurred in the same ISP region, 135±12.5 mm Hg, where reflex control of total peripheral resistance was strongest. The total volume shift was approximately 7.5 ml/kg for ISP changes from 75 to 200 mm Hg. When mean arterial blood pressure was maintained constant during the ISP step changes, the volume shift almost doubled. In experiments measuring the reflex effect on total systemic vascular compliance (series 2) and in experiments determining the reflex control of arterial complicance (series 3), total systemic vascular and lumped arterial compliances were measured in the same dogs that were used in series 1 experiments. The total systemic vascular and arterial compliances were approximately 2.0 ml/mm Hg kg-1 and 0.0677 ml/mm Hg kg-1, respectively. The reflex did not affect these compliances. The authors concluded that the reflex controls the total systemic venous capacity to a degree that changes output potentially by 30-40{\%} per 25 mm Hg change in ISP.",
author = "Shoukas, {Artin A} and K. Sagawa",
year = "1973",
language = "English (US)",
volume = "33",
pages = "22--33",
journal = "Circulation Research",
issn = "0009-7330",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Control of total systemic vascular capacity by the carotid sinus baroreceptor reflex

AU - Shoukas, Artin A

AU - Sagawa, K.

PY - 1973

Y1 - 1973

N2 - To attain a quantitative understanding of carotid sinus baroreceptor reflex control of cardiac output the authors studied the reflex control of total systemic vascular capacity in vagotomized dogs. In experiments measuring blood volume shifts caused by the carotid sinus reflex (series 1), venous return was diverted into a reservoir while cardiac output and central venous pressure were maintained at constant levels. The pressure in the isolated carotid sinuses (ISP) was lowered or raised in 25 mm Hg steps between 75 and 200 mm Hg. This procedure mobilized blood into or out of the reservoir, indicating a decrease or an increase in total vascular capacity, respectively. The mean maximum volume shift, 3.6 ml/kg body weight, occurred in the same ISP region, 135±12.5 mm Hg, where reflex control of total peripheral resistance was strongest. The total volume shift was approximately 7.5 ml/kg for ISP changes from 75 to 200 mm Hg. When mean arterial blood pressure was maintained constant during the ISP step changes, the volume shift almost doubled. In experiments measuring the reflex effect on total systemic vascular compliance (series 2) and in experiments determining the reflex control of arterial complicance (series 3), total systemic vascular and lumped arterial compliances were measured in the same dogs that were used in series 1 experiments. The total systemic vascular and arterial compliances were approximately 2.0 ml/mm Hg kg-1 and 0.0677 ml/mm Hg kg-1, respectively. The reflex did not affect these compliances. The authors concluded that the reflex controls the total systemic venous capacity to a degree that changes output potentially by 30-40% per 25 mm Hg change in ISP.

AB - To attain a quantitative understanding of carotid sinus baroreceptor reflex control of cardiac output the authors studied the reflex control of total systemic vascular capacity in vagotomized dogs. In experiments measuring blood volume shifts caused by the carotid sinus reflex (series 1), venous return was diverted into a reservoir while cardiac output and central venous pressure were maintained at constant levels. The pressure in the isolated carotid sinuses (ISP) was lowered or raised in 25 mm Hg steps between 75 and 200 mm Hg. This procedure mobilized blood into or out of the reservoir, indicating a decrease or an increase in total vascular capacity, respectively. The mean maximum volume shift, 3.6 ml/kg body weight, occurred in the same ISP region, 135±12.5 mm Hg, where reflex control of total peripheral resistance was strongest. The total volume shift was approximately 7.5 ml/kg for ISP changes from 75 to 200 mm Hg. When mean arterial blood pressure was maintained constant during the ISP step changes, the volume shift almost doubled. In experiments measuring the reflex effect on total systemic vascular compliance (series 2) and in experiments determining the reflex control of arterial complicance (series 3), total systemic vascular and lumped arterial compliances were measured in the same dogs that were used in series 1 experiments. The total systemic vascular and arterial compliances were approximately 2.0 ml/mm Hg kg-1 and 0.0677 ml/mm Hg kg-1, respectively. The reflex did not affect these compliances. The authors concluded that the reflex controls the total systemic venous capacity to a degree that changes output potentially by 30-40% per 25 mm Hg change in ISP.

UR - http://www.scopus.com/inward/record.url?scp=0015843148&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015843148&partnerID=8YFLogxK

M3 - Article

VL - 33

SP - 22

EP - 33

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

IS - 1

ER -