Control of LH and FSH secretion in the male: Evidence that aromatization of androgens to estradiol is not required for inhibition of gonadotropin secretion

Ronald S. Swerdloff, Patrick C. Walsh, William D. Odell

Research output: Contribution to journalArticle

Abstract

Recent data indicate that the hypothalamus is capable of aromatizing androgens to estrogens; it has been suggested that this aromatization is required for hormonal activity at the hypothalamic level. In this study dihydrotestosterone and testosterone were administered over a broad dose range to castrate male rats. Dihydrotestosterone, an A-ring reduced steroid which is not convertible to estrogen, was demonstrated to be more potent than testosterone in suppressing serum LH levels while equipotent to testosterone in suppressing FSH. We conclude that conversion of androgens to estrogens is not required for inhibition of the hypothalamic-pituitary axis.

Original languageEnglish (US)
Pages (from-to)13-22
Number of pages10
JournalSteroids
Volume20
Issue number1
DOIs
StatePublished - Jul 1972
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Control of LH and FSH secretion in the male: Evidence that aromatization of androgens to estradiol is not required for inhibition of gonadotropin secretion'. Together they form a unique fingerprint.

Cite this