Control of HPV infection and related cancer through vaccination

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Human papillomavirus (HPV), the most common sexually transmitted virus, and its associated diseases continue to cause significant morbidity and mortality in over 600 million infected individuals. Major progress has been made with preventative vaccines, and clinical data have emerged regarding the efficacy and cross-reactivity of the two FDA approved L1 virus like particle (VLP)-based vaccines. However, the cost of the approved vaccines currently limits their widespread use in developing countries which carry the greatest burden of HPV-associated diseases. Furthermore, the licensed preventive HPV vaccines only contain two high-risk types of HPV (HPV-16 and HPV-18) which can protect only up to 75 % of all cervical cancers. Thus, second generation preventative vaccine candidates hope to address the issues of cost and broaden protection through the use of more multivalent L1-VLPs, vaccine formulations, or alternative antigens such as L1 capsomers, L2 capsid proteins, and chimeric VLPs. Preventative vaccines are crucial to controlling the transmission of HPV, but there are already hundreds of millions of infected individuals who have HPV-associated lesions that are silently progressing toward malignancy. This raises the need for therapeutic HPV vaccines that can trigger T cell killing of established HPV lesions, including HPV-transformed tumor cells. In order to stimulate such antitumor immune responses, therapeutic vaccine candidates deliver HPV antigens in vivo by employing various bacterial, viral, protein, peptide, dendritic cell, and DNA-based vectors. This book chapter will review the commercially available preventive vaccines, present second generation candidates, and discuss the progress of developing therapeutic HPV vaccines.

Original languageEnglish (US)
Title of host publicationViruses and Human Cancer
Subtitle of host publicationFrom Basic Science to Clinical Prevention
PublisherSpringer New York LLC
Pages149-171
Number of pages23
ISBN (Print)9783642389641
DOIs
StatePublished - Jan 1 2014

Publication series

NameRecent Results in Cancer Research
Volume193
ISSN (Print)0080-0015

Keywords

  • Cancer
  • Human Papillomavirus (HPV)
  • Immunotherapy
  • Vaccines
  • Virus like particle (VLP)

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Tran, N. P., Hung, C. F., Roden, R., & Wu, T. C. (2014). Control of HPV infection and related cancer through vaccination. In Viruses and Human Cancer: From Basic Science to Clinical Prevention (pp. 149-171). (Recent Results in Cancer Research; Vol. 193). Springer New York LLC. https://doi.org/10.1007/978-3-642-38965-8_9