Control of germline stem cell lineages by diet and physiology

Kaitlin M. Laws, Daniela Drummond Barbosa

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Tight coupling of reproduction to environmental factors and physiological status is key to long-term species survival. In particular, highly conserved pathways modulate germline stem cell lineages according to nutrient availability. This chapter focuses on recent in vivo studies in genetic model organisms that shed light on how diet-dependent signals control the proliferation, maintenance, and survival of adult germline stem cells and their progeny. These signaling pathways can operate intrinsically in the germ line, modulate the niche, or act through intermediate organs to influence stem cells and their differentiating progeny. In addition to illustrating the extent of dietary regulation of reproduction, findings from these studies have implications for fertility during aging or disease states.

Original languageEnglish (US)
Title of host publicationResults and Problems in Cell Differentiation
PublisherSpringer Verlag
Pages67-99
Number of pages33
Volume59
DOIs
StatePublished - 2017

Publication series

NameResults and Problems in Cell Differentiation
Volume59
ISSN (Print)00801844
ISSN (Electronic)18610412

Fingerprint

Cell Physiological Phenomena
Cell Lineage
Reproduction
Stem Cells
Diet
Genetic Models
Germ Cells
Fertility
Maintenance
Food
Adult Germline Stem Cells

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Laws, K. M., & Barbosa, D. D. (2017). Control of germline stem cell lineages by diet and physiology. In Results and Problems in Cell Differentiation (Vol. 59, pp. 67-99). (Results and Problems in Cell Differentiation; Vol. 59). Springer Verlag. https://doi.org/10.1007/978-3-319-44820-6_3

Control of germline stem cell lineages by diet and physiology. / Laws, Kaitlin M.; Barbosa, Daniela Drummond.

Results and Problems in Cell Differentiation. Vol. 59 Springer Verlag, 2017. p. 67-99 (Results and Problems in Cell Differentiation; Vol. 59).

Research output: Chapter in Book/Report/Conference proceedingChapter

Laws, KM & Barbosa, DD 2017, Control of germline stem cell lineages by diet and physiology. in Results and Problems in Cell Differentiation. vol. 59, Results and Problems in Cell Differentiation, vol. 59, Springer Verlag, pp. 67-99. https://doi.org/10.1007/978-3-319-44820-6_3
Laws KM, Barbosa DD. Control of germline stem cell lineages by diet and physiology. In Results and Problems in Cell Differentiation. Vol. 59. Springer Verlag. 2017. p. 67-99. (Results and Problems in Cell Differentiation). https://doi.org/10.1007/978-3-319-44820-6_3
Laws, Kaitlin M. ; Barbosa, Daniela Drummond. / Control of germline stem cell lineages by diet and physiology. Results and Problems in Cell Differentiation. Vol. 59 Springer Verlag, 2017. pp. 67-99 (Results and Problems in Cell Differentiation).
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