TY - CHAP
T1 - Control of germline stem cell lineages by diet and physiology
AU - Laws, Kaitlin M.
AU - Drummond-Barbosa, Daniela
N1 - Publisher Copyright:
© Springer International Publishing Switzerland 2017.
PY - 2017
Y1 - 2017
N2 - Tight coupling of reproduction to environmental factors and physiological status is key to long-term species survival. In particular, highly conserved pathways modulate germline stem cell lineages according to nutrient availability. This chapter focuses on recent in vivo studies in genetic model organisms that shed light on how diet-dependent signals control the proliferation, maintenance, and survival of adult germline stem cells and their progeny. These signaling pathways can operate intrinsically in the germ line, modulate the niche, or act through intermediate organs to influence stem cells and their differentiating progeny. In addition to illustrating the extent of dietary regulation of reproduction, findings from these studies have implications for fertility during aging or disease states.
AB - Tight coupling of reproduction to environmental factors and physiological status is key to long-term species survival. In particular, highly conserved pathways modulate germline stem cell lineages according to nutrient availability. This chapter focuses on recent in vivo studies in genetic model organisms that shed light on how diet-dependent signals control the proliferation, maintenance, and survival of adult germline stem cells and their progeny. These signaling pathways can operate intrinsically in the germ line, modulate the niche, or act through intermediate organs to influence stem cells and their differentiating progeny. In addition to illustrating the extent of dietary regulation of reproduction, findings from these studies have implications for fertility during aging or disease states.
UR - http://www.scopus.com/inward/record.url?scp=85014136160&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85014136160&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-44820-6_3
DO - 10.1007/978-3-319-44820-6_3
M3 - Chapter
C2 - 28247046
AN - SCOPUS:85014136160
T3 - Results and Problems in Cell Differentiation
SP - 67
EP - 99
BT - Results and Problems in Cell Differentiation
PB - Springer Verlag
ER -