Control of foxo1 gene expression by co-activator p300

Anne R. Wondisford; Lishou Xiong; Evan Chang; Shumei Meng; David J. Meyers; Mingsong Li; Philip A. Cole; Ling He

doi:10.1074/jbc.M113.540500

Control of foxo1 gene expression by co-activator p300

Anne R. Wondisford, Lishou Xiong, Evan Chang, Shumei Meng, David J. Meyers, Mingsong Li, Philip A. Cole, Ling He

School of Medicine

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Background: The mechanism driving hepatic gene expression of Foxo1 in the fasted state remains unclear. Results: Activation of cAMP-PKA pathway induces Foxo1 gene expression through CREB and co-activator P300. Conclusion: P300 mediates Foxo1 gene expression by binding to Foxo1 proximal promoter. Significance: Induction of the Foxo1 gene by cAMP-PKA via P300 fully activates the gluconeogenic program during fasting to maintain euglycemia.

Original language	English (US)
Pages (from-to)	4326-4333
Number of pages	8
Journal	Journal of Biological Chemistry
Volume	289
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M113.540500
State	Published - Feb 14 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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abstract = "Background: The mechanism driving hepatic gene expression of Foxo1 in the fasted state remains unclear. Results: Activation of cAMP-PKA pathway induces Foxo1 gene expression through CREB and co-activator P300. Conclusion: P300 mediates Foxo1 gene expression by binding to Foxo1 proximal promoter. Significance: Induction of the Foxo1 gene by cAMP-PKA via P300 fully activates the gluconeogenic program during fasting to maintain euglycemia.",

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AU - Wondisford, Anne R.

AU - Xiong, Lishou

AU - Chang, Evan

AU - Meng, Shumei

AU - Meyers, David J.

AU - Li, Mingsong

AU - Cole, Philip A.

AU - He, Ling

PY - 2014/2/14

Y1 - 2014/2/14

N2 - Background: The mechanism driving hepatic gene expression of Foxo1 in the fasted state remains unclear. Results: Activation of cAMP-PKA pathway induces Foxo1 gene expression through CREB and co-activator P300. Conclusion: P300 mediates Foxo1 gene expression by binding to Foxo1 proximal promoter. Significance: Induction of the Foxo1 gene by cAMP-PKA via P300 fully activates the gluconeogenic program during fasting to maintain euglycemia.

AB - Background: The mechanism driving hepatic gene expression of Foxo1 in the fasted state remains unclear. Results: Activation of cAMP-PKA pathway induces Foxo1 gene expression through CREB and co-activator P300. Conclusion: P300 mediates Foxo1 gene expression by binding to Foxo1 proximal promoter. Significance: Induction of the Foxo1 gene by cAMP-PKA via P300 fully activates the gluconeogenic program during fasting to maintain euglycemia.

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Control of foxo1 gene expression by co-activator p300

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