Control of foxo1 gene expression by co-activator p300

Anne R. Wondisford, Lishou Xiong, Evan Chang, Shumei Meng, David J. Meyers, Mingsong Li, Philip A. Cole, Ling He

Research output: Contribution to journalArticle

Abstract

Background: The mechanism driving hepatic gene expression of Foxo1 in the fasted state remains unclear. Results: Activation of cAMP-PKA pathway induces Foxo1 gene expression through CREB and co-activator P300. Conclusion: P300 mediates Foxo1 gene expression by binding to Foxo1 proximal promoter. Significance: Induction of the Foxo1 gene by cAMP-PKA via P300 fully activates the gluconeogenic program during fasting to maintain euglycemia.

Original languageEnglish (US)
Pages (from-to)4326-4333
Number of pages8
JournalJournal of Biological Chemistry
Volume289
Issue number7
DOIs
StatePublished - Feb 14 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Wondisford, A. R., Xiong, L., Chang, E., Meng, S., Meyers, D. J., Li, M., Cole, P. A., & He, L. (2014). Control of foxo1 gene expression by co-activator p300. Journal of Biological Chemistry, 289(7), 4326-4333. https://doi.org/10.1074/jbc.M113.540500