TY - GEN
T1 - Control of Chemotaxis Through Absolute Concentration Robustness
AU - Bhattacharya, Sayak
AU - Biswas, Debojyoti
AU - Enciso, German A.
AU - Iglesias, Pablo A.
N1 - Funding Information:
This work was supported by DARPA under contract number HR0011-16-C-0139 SB is with Department Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD, USA sbhatt11@jhu.edu DB is with Department Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD, USA dbiswas2@jhu.edu GAE is with Faculty of Mathematics, University of California, Irvine, CA, USA enciso@uci.edu PAI is with Faculty of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD, USA pi@jhu.edu
Publisher Copyright:
© 2018 IEEE.
PY - 2018/7/2
Y1 - 2018/7/2
N2 - Chemotaxis, the directed motion of cells in response to chemical gradients, is important for a variety of biological processes ranging from embryogenesis to killing of pathogens. Increasing the speed and efficiency of directed migration is critical in such situations. We provide a control mechanism by which one can minimize the noise-driven firings at the back of the cell, enabling faster motion towards the front. We achieve this through a mechanism called absolute concentration robustness (ACR), which robustly maintains the steady-state concentration of intracellular biochemical species and, at the same time, provides control over the concentration variance. More particularly, by incorporating ACR, we develop a correspondence between the concentration mean and variance - both of which are independent of total concentrations. We show that by incorporating ACR into the back of a moving cell, we can create a mechanism to robustly control the noise variance at the back - thus limiting the deterring firings while the cell moves in the direction of the gradient.
AB - Chemotaxis, the directed motion of cells in response to chemical gradients, is important for a variety of biological processes ranging from embryogenesis to killing of pathogens. Increasing the speed and efficiency of directed migration is critical in such situations. We provide a control mechanism by which one can minimize the noise-driven firings at the back of the cell, enabling faster motion towards the front. We achieve this through a mechanism called absolute concentration robustness (ACR), which robustly maintains the steady-state concentration of intracellular biochemical species and, at the same time, provides control over the concentration variance. More particularly, by incorporating ACR, we develop a correspondence between the concentration mean and variance - both of which are independent of total concentrations. We show that by incorporating ACR into the back of a moving cell, we can create a mechanism to robustly control the noise variance at the back - thus limiting the deterring firings while the cell moves in the direction of the gradient.
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U2 - 10.1109/CDC.2018.8619195
DO - 10.1109/CDC.2018.8619195
M3 - Conference contribution
AN - SCOPUS:85062165771
T3 - Proceedings of the IEEE Conference on Decision and Control
SP - 4360
EP - 4365
BT - 2018 IEEE Conference on Decision and Control, CDC 2018
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 57th IEEE Conference on Decision and Control, CDC 2018
Y2 - 17 December 2018 through 19 December 2018
ER -