CONTROL OF ACETYLCHOLINE SYNTHESIS—THE INHIBITION OF CHOLINE ACETYLTRANSFERASE BY ACETYLCHOLINE

A. A. Kaita, A. M. Goldberg

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract— The inhibition of choline acetyltransferase by acetylcholine in vitro occurs at a concentration of 10 mm and increases progressively to 45 per cent at a concentration of 100 mm. The inhibition is competitive for choline and noncompetitive for acetyl‐CoA. It is suggested that the synthesis of acetylcholine may be controlled by its accumulation in synaptic vesicles.

Original languageEnglish (US)
Pages (from-to)1185-1191
Number of pages7
JournalJournal of Neurochemistry
Volume16
Issue number7
DOIs
StatePublished - Jul 1969
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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