CONTROL OF ACETYLCHOLINE SYNTHESIS—THE INHIBITION OF CHOLINE ACETYLTRANSFERASE BY ACETYLCHOLINE

A. A. Kaita; A. M. Goldberg

doi:10.1111/j.1471-4159.1969.tb05964.x

CONTROL OF ACETYLCHOLINE SYNTHESIS—THE INHIBITION OF CHOLINE ACETYLTRANSFERASE BY ACETYLCHOLINE

A. A. Kaita, A. M. Goldberg

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Abstract

Abstract— The inhibition of choline acetyltransferase by acetylcholine in vitro occurs at a concentration of 10 mm and increases progressively to 45 per cent at a concentration of 100 mm. The inhibition is competitive for choline and noncompetitive for acetyl‐CoA. It is suggested that the synthesis of acetylcholine may be controlled by its accumulation in synaptic vesicles.

Original language	English (US)
Pages (from-to)	1185-1191
Number of pages	7
Journal	Journal of Neurochemistry
Volume	16
Issue number	7
DOIs	https://doi.org/10.1111/j.1471-4159.1969.tb05964.x
State	Published - Jul 1969
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

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10.1111/j.1471-4159.1969.tb05964.x

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abstract = "Abstract— The inhibition of choline acetyltransferase by acetylcholine in vitro occurs at a concentration of 10 mm and increases progressively to 45 per cent at a concentration of 100 mm. The inhibition is competitive for choline and noncompetitive for acetyl‐CoA. It is suggested that the synthesis of acetylcholine may be controlled by its accumulation in synaptic vesicles.",

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CONTROL OF ACETYLCHOLINE SYNTHESIS—THE INHIBITION OF CHOLINE ACETYLTRANSFERASE BY ACETYLCHOLINE

Abstract

ASJC Scopus subject areas

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