"Control" laboratory rodents are metabolically morbid: Why it matters

Bronwen Martin, Sunggoan Ji, Stuart Maudsley, Mark P. Mattson

Research output: Contribution to journalArticle

Abstract

Failure to recognize that many standard control rats and mice used in biomedical research are sedentary, obese, glucose intolerant, and on a trajectory to premature death may confound data interpretation and outcomes of human studies. Fundamental aspects of cellular physiology, vulnerability to oxidative stress, inflammation, and associated diseases are among the many biological processes affected by dietary energy intake and exercise. Although overfed sedentary rodents may be reasonable models for the study of obesity in humans, treatments shown to be efficacious in these animal models may prove ineffective or exhibit novel side effects in active, normalweight subjects.

Original languageEnglish (US)
Pages (from-to)6127-6133
Number of pages7
JournalProceedings of the National Academy of Sciences of the United States of America
Volume107
Issue number14
DOIs
StatePublished - Apr 6 2010
Externally publishedYes

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Keywords

  • Cancer
  • Clinical trials
  • Exercise
  • Insulin resistance
  • Obesity

ASJC Scopus subject areas

  • General

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