Abstract
The pattern of flux and concentration control coefficients in an integrated mitochondrial energetics model is examined by applying a generalized matrix method of control analysis to calculate control coefficients, as well as response coefficients The computational model of Cortassa et al. encompasses oxidative phosphorylation, the TCA cycle, and Ca2+ dynamics. Control of ATP synthesis, TCA cycle, and ANT fluxes were found to be distributed among various mitochondrial processes. Control is shared by processes associated with ATP/ADP production and transport, as well as by Ca2+ dynamics. The calculation also analyzed the control of the concentrations of key regulatory ions and metabolites (Ca2+, NADH, ADP). The approach we have used demonstrates how properties of integrated systems may be understood through applications of computational modeling and control analysis.
Original language | English (US) |
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Pages (from-to) | 1500-1513 |
Number of pages | 14 |
Journal | International journal of molecular sciences |
Volume | 10 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2009 |
Keywords
- Calcium dynamics
- Control by diffuse loops
- Distributed control
- Excitationcontraction coupling
- Metabolic control analysis
- Mitochondrial computational model
- Mitochondrial energetics
ASJC Scopus subject areas
- Catalysis
- Molecular Biology
- Spectroscopy
- Computer Science Applications
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry