Contributions of the cerebellum and the motor cortex to acquisition and retention of motor memories

David J. Herzfeld, Damien Pastor, Adrian Haith, Yves Rossetti, Reza Shadmehr, Jacinta O'Shea

Research output: Contribution to journalArticle

Abstract

We investigated the contributions of the cerebellum and the motor cortex (M1) to acquisition and retention of human motor memories in a force field reaching task. We found that anodal transcranial direct current stimulation (tDCS) of the cerebellum, a technique that is thought to increase neuronal excitability, increased the ability to learn from error and form an internal model of the field, while cathodal cerebellar stimulation reduced this error-dependent learning. In addition, cathodal cerebellar stimulation disrupted the ability to respond to error within a reaching movement, reducing the gain of the sensory-motor feedback loop. By contrast, anodal M1 stimulation had no significant effects on these variables. During sham stimulation, early in training the acquired motor memory exhibited rapid decay in error-clamp trials. With further training the rate of decay decreased, suggesting that with training the motor memory was transformed from a labile to a more stable state. Surprisingly, neither cerebellar nor M1 stimulation altered these decay patterns. Participants returned 24. hours later and were re-tested in error-clamp trials without stimulation. The cerebellar group that had learned the task with cathodal stimulation exhibited significantly impaired retention, and retention was not improved by M1 anodal stimulation. In summary, non-invasive cerebellar stimulation resulted in polarity-dependent up- or down-regulation of error-dependent motor learning. In addition, cathodal cerebellar stimulation during acquisition impaired the ability to retain the motor memory overnight. Thus, in the force field task we found a critical role for the cerebellum in both formation of motor memory and its retention.

Original languageEnglish (US)
Pages (from-to)147-158
Number of pages12
JournalNeuroImage
Volume98
DOIs
StatePublished - 2014

Fingerprint

Motor Cortex
Cerebellum
Aptitude
Learning
Sensory Feedback
Advisory Committees
Up-Regulation
Down-Regulation
Retention (Psychology)

Keywords

  • Adaptation
  • Consolidation
  • Force field
  • Generalization
  • Motor control
  • Reaching
  • Retention
  • TDCS

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology
  • Medicine(all)

Cite this

Contributions of the cerebellum and the motor cortex to acquisition and retention of motor memories. / Herzfeld, David J.; Pastor, Damien; Haith, Adrian; Rossetti, Yves; Shadmehr, Reza; O'Shea, Jacinta.

In: NeuroImage, Vol. 98, 2014, p. 147-158.

Research output: Contribution to journalArticle

Herzfeld, David J. ; Pastor, Damien ; Haith, Adrian ; Rossetti, Yves ; Shadmehr, Reza ; O'Shea, Jacinta. / Contributions of the cerebellum and the motor cortex to acquisition and retention of motor memories. In: NeuroImage. 2014 ; Vol. 98. pp. 147-158.
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