TY - JOUR
T1 - Contributions of an internalizing symptoms polygenic risk score and contextual factors to alcohol-related disorders in african american young adults
AU - Rabinowitz, Jill Alexandra
AU - Musci, Rashelle
AU - Milam, Adam
AU - Benke, Kelly
AU - Sisto, Danielle
AU - Ialongo, Nicholas S.
AU - Maher, Brion S.
AU - Uhl, George
AU - Rosenbaum, Gail
AU - Reboussin, Beth
N1 - Publisher Copyright:
© 2019, Alcohol Research Documentation Inc.. All rights reserved.
PY - 2019/1
Y1 - 2019/1
N2 - Objective: Alcohol-related disorders (i.e., abuse and de-pendence) are significant problems that may result in numerous negative consequences. Although a number of studies have examined factors that predict alcohol abuse and dependence in European samples, only a few studies have examined whether genetic and environmental factors influence the pathogenesis of alcohol-related disorders among African Americans. The present study examined whether gene (internalizing symptoms polygenic risk score) by environment (parental monitoring, community disadvantage) interactions were associated with alcohol-related disorders in a sample of African American adults. Method: Participants (N = 640; 39.7% male) were initially recruited for an elementary school–based universal prevention trial in a mid-Atlantic city and followed into adulthood. Participants reported on their perceptions of parental monitoring in sixth grade. At 30 years of age, participants reported on their alcohol abuse and dependence, and DNA was obtained and genotyped using Affymetrix 6.0 microarrays. An internalizing symptoms polygenic risk score was created using discovery samples results from a genome-wide association study (GWAS) that involved three large population-based studies. Community disadvantage was calculated based on census data when participants were in first grade. Results: There was a significant interaction between the internalizing symptoms polygenic risk score and community disadvantage such that exposure to higher community disadvantage was associated with lower risk for alcohol-related disorders among participants with a higher internalizing symptoms polygenic risk score. Conclusions: Our findings highlight that higher genetic loading for internalizing symptoms may protect urban African Americans from alcohol-related disorders, particularly in more disadvantaged areas.
AB - Objective: Alcohol-related disorders (i.e., abuse and de-pendence) are significant problems that may result in numerous negative consequences. Although a number of studies have examined factors that predict alcohol abuse and dependence in European samples, only a few studies have examined whether genetic and environmental factors influence the pathogenesis of alcohol-related disorders among African Americans. The present study examined whether gene (internalizing symptoms polygenic risk score) by environment (parental monitoring, community disadvantage) interactions were associated with alcohol-related disorders in a sample of African American adults. Method: Participants (N = 640; 39.7% male) were initially recruited for an elementary school–based universal prevention trial in a mid-Atlantic city and followed into adulthood. Participants reported on their perceptions of parental monitoring in sixth grade. At 30 years of age, participants reported on their alcohol abuse and dependence, and DNA was obtained and genotyped using Affymetrix 6.0 microarrays. An internalizing symptoms polygenic risk score was created using discovery samples results from a genome-wide association study (GWAS) that involved three large population-based studies. Community disadvantage was calculated based on census data when participants were in first grade. Results: There was a significant interaction between the internalizing symptoms polygenic risk score and community disadvantage such that exposure to higher community disadvantage was associated with lower risk for alcohol-related disorders among participants with a higher internalizing symptoms polygenic risk score. Conclusions: Our findings highlight that higher genetic loading for internalizing symptoms may protect urban African Americans from alcohol-related disorders, particularly in more disadvantaged areas.
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U2 - 10.15288/jsad.2019.80.77
DO - 10.15288/jsad.2019.80.77
M3 - Article
C2 - 30807278
AN - SCOPUS:85062381381
SN - 1937-1888
VL - 80
SP - 77
EP - 85
JO - Journal of studies on alcohol and drugs
JF - Journal of studies on alcohol and drugs
IS - 1
ER -