TY - JOUR
T1 - Contribution of platelets indices in the development of contrast-induced nephropathy
AU - Sahin, Irfan
AU - Karabulut, Ahmet
AU - Avci, Ilhan Iker
AU - Okuyan, Ertugrul
AU - Biter, Halil I.
AU - Yildiz, Suleyman S.
AU - Can, Mehmet M.
AU - Gungor, Baris
AU - Dinckal, Mustafa
AU - Serebruany, Victor
PY - 2015/4/7
Y1 - 2015/4/7
N2 - Contrast-induced nephropathy (CIN) accounts for 10% of hospital-acquired renal failure, causes a prolonged in-hospital stay and represents a powerful predictor of poor clinical outcome. The underlying mechanism of the CIN development remains unclear and seems to be multifactorial. The potential link between platelet indices such as mean platelet volume (MPV) and platelet distribution width (PDW) with CIN is unknown. Herein, we aimed to investigate the correlation between MPV and PDW levels with the development of CIN. The incidence of CIN (20.5%) was prospectively evaluated in 430 patients with diagnosis of acute coronary syndrome. Initial creatinine (1.13±0.25 vs. 1.05±0.27mg/dl, P=0.01) and PDW (40.1±20.2 vs. 34.5±19.9%, P=0.02) levels and the total volume of contrast media used (121±61 vs. 94±42ml, P=0.01) were higher in patients who developed CIN. MPV was similar between the two groups (P=0.80). In a univariate regression analysis, age, increased creatinine, uric acid, phosphate, PDW levels and higher total volume of contrast media used were significantly correlated with CIN incidence. However, in a multivariate analysis, only total volume of CM used [odds ratio (OR) 1.011, 95% confidence interval (CI) 1.006-1.016; P=0.01], increased age (OR 1.026, 95% CI 1.00-1.052; P=0.05) and increased PDW levels (OR 1.009, 95% CI 1.00-1.022; P=0.04) remained as the independent predictors of CIN. Among platelet indices, PDW, but not MPV, was associated with CIN development. The clinical significance of such link remains unclear, but may indicate involvement of platelet activation in CIN pathogenesis.
AB - Contrast-induced nephropathy (CIN) accounts for 10% of hospital-acquired renal failure, causes a prolonged in-hospital stay and represents a powerful predictor of poor clinical outcome. The underlying mechanism of the CIN development remains unclear and seems to be multifactorial. The potential link between platelet indices such as mean platelet volume (MPV) and platelet distribution width (PDW) with CIN is unknown. Herein, we aimed to investigate the correlation between MPV and PDW levels with the development of CIN. The incidence of CIN (20.5%) was prospectively evaluated in 430 patients with diagnosis of acute coronary syndrome. Initial creatinine (1.13±0.25 vs. 1.05±0.27mg/dl, P=0.01) and PDW (40.1±20.2 vs. 34.5±19.9%, P=0.02) levels and the total volume of contrast media used (121±61 vs. 94±42ml, P=0.01) were higher in patients who developed CIN. MPV was similar between the two groups (P=0.80). In a univariate regression analysis, age, increased creatinine, uric acid, phosphate, PDW levels and higher total volume of contrast media used were significantly correlated with CIN incidence. However, in a multivariate analysis, only total volume of CM used [odds ratio (OR) 1.011, 95% confidence interval (CI) 1.006-1.016; P=0.01], increased age (OR 1.026, 95% CI 1.00-1.052; P=0.05) and increased PDW levels (OR 1.009, 95% CI 1.00-1.022; P=0.04) remained as the independent predictors of CIN. Among platelet indices, PDW, but not MPV, was associated with CIN development. The clinical significance of such link remains unclear, but may indicate involvement of platelet activation in CIN pathogenesis.
KW - contrast-induced nephropathy
KW - pathophysiology
KW - platelet distribution width
UR - http://www.scopus.com/inward/record.url?scp=84926513535&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84926513535&partnerID=8YFLogxK
U2 - 10.1097/MBC.0000000000000107
DO - 10.1097/MBC.0000000000000107
M3 - Article
C2 - 24695089
AN - SCOPUS:84926513535
SN - 0957-5235
VL - 26
SP - 246
EP - 249
JO - Blood Coagulation and Fibrinolysis
JF - Blood Coagulation and Fibrinolysis
IS - 3
ER -