Contribution of modifiable risk factors for hypertension and type-2 diabetes in Peruvian resource-limited settings

CRONICAS Cohort Study Group

Research output: Contribution to journalArticle

Abstract

Background It is important to understand the local burden of non-communicable diseases including withincountry heterogeneity. The aim of this study was to characterise hypertension and type-2 diabetes profiles across different Peruvian geographical settings emphasising the assessment of modifiable risk factors. Methods Analysis of the CRONICAS Cohort Study baseline assessment was conducted. Cardiometabolic outcomes were blood pressure categories (hypertension, prehypertension, normal) and glucose metabolism disorder status (diabetes, prediabetes, normal). Exposures were study setting and six modifiable factors (smoking, alcohol drinking, leisure time and transportrelated physical activity levels, TV watching, fruit/ vegetables intake and obesity). Poisson regression models were used to report prevalence ratios (PR). Population attributable risks (PAR) were also estimated. Results Data from 3238 participants, 48.3% male, mean age 45.3 years, were analysed. Age-standardised (WHO population) prevalence of prehypertension and hypertension was 24% and 16%, whereas for prediabetes and type-2 diabetes it was 18% and 6%, respectively. Outcomes varied according to study setting (p <0.001). In multivariable model, hypertension was higher among daily smokers (PR 1.76), heavy alcohol drinkers (PR 1.61) and the obese (PR 2.06); whereas only obesity (PR 2.26) increased the prevalence of diabetes. PAR showed that obesity was an important determinant for hypertension (15.7%) and type-2 diabetes (23.9%). Conclusions There is an evident heterogeneity in the prevalence of and risk factors for hypertension and diabetes within Peru. Prehypertension and prediabetes are highly prevalent across settings. Our results emphasise the need of understanding the epidemiology of cardiometabolic conditions to appropriately implement interventions to tackle the burden of non-communicable diseases.

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
JournalJournal of Epidemiology and Community Health
Volume70
Issue number1
DOIs
StatePublished - Aug 6 2015

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Type 2 Diabetes Mellitus
Hypertension
Prehypertension
Prediabetic State
Obesity
Glucose Metabolism Disorders
Population
Peru
Leisure Activities
Alcohol Drinking
Vegetables
Fruit
Epidemiology
Cohort Studies
Smoking
Alcohols
Blood Pressure

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Epidemiology

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Contribution of modifiable risk factors for hypertension and type-2 diabetes in Peruvian resource-limited settings. / CRONICAS Cohort Study Group.

In: Journal of Epidemiology and Community Health, Vol. 70, No. 1, 06.08.2015, p. 49-55.

Research output: Contribution to journalArticle

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abstract = "Background It is important to understand the local burden of non-communicable diseases including withincountry heterogeneity. The aim of this study was to characterise hypertension and type-2 diabetes profiles across different Peruvian geographical settings emphasising the assessment of modifiable risk factors. Methods Analysis of the CRONICAS Cohort Study baseline assessment was conducted. Cardiometabolic outcomes were blood pressure categories (hypertension, prehypertension, normal) and glucose metabolism disorder status (diabetes, prediabetes, normal). Exposures were study setting and six modifiable factors (smoking, alcohol drinking, leisure time and transportrelated physical activity levels, TV watching, fruit/ vegetables intake and obesity). Poisson regression models were used to report prevalence ratios (PR). Population attributable risks (PAR) were also estimated. Results Data from 3238 participants, 48.3{\%} male, mean age 45.3 years, were analysed. Age-standardised (WHO population) prevalence of prehypertension and hypertension was 24{\%} and 16{\%}, whereas for prediabetes and type-2 diabetes it was 18{\%} and 6{\%}, respectively. Outcomes varied according to study setting (p <0.001). In multivariable model, hypertension was higher among daily smokers (PR 1.76), heavy alcohol drinkers (PR 1.61) and the obese (PR 2.06); whereas only obesity (PR 2.26) increased the prevalence of diabetes. PAR showed that obesity was an important determinant for hypertension (15.7{\%}) and type-2 diabetes (23.9{\%}). Conclusions There is an evident heterogeneity in the prevalence of and risk factors for hypertension and diabetes within Peru. Prehypertension and prediabetes are highly prevalent across settings. Our results emphasise the need of understanding the epidemiology of cardiometabolic conditions to appropriately implement interventions to tackle the burden of non-communicable diseases.",
author = "{CRONICAS Cohort Study Group} and Antonio Bernab{\'e}-Ortiz and Carrillo-Larco, {Rodrigo M.} and Gilman, {Robert H} and William Checkley and Liam Smeeth and Miranda, {J. Jaime} and Casas, {Juan P.} and Smith, {George Davey} and Shah Ebrahim and Garc{\'i}a, {H{\'e}ctor H.} and Luis Huicho and Germ{\'a}n M{\'a}laga and Montori, {V{\'i}ctor M.} and Diette, {Gregory B} and Fabiola Le{\'o}n-Velarde and Mar{\'i}a Rivera and Wise, {Robert A} and Katherine Sacksteder",
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AU - CRONICAS Cohort Study Group

AU - Bernabé-Ortiz, Antonio

AU - Carrillo-Larco, Rodrigo M.

AU - Gilman, Robert H

AU - Checkley, William

AU - Smeeth, Liam

AU - Miranda, J. Jaime

AU - Casas, Juan P.

AU - Smith, George Davey

AU - Ebrahim, Shah

AU - García, Héctor H.

AU - Huicho, Luis

AU - Málaga, Germán

AU - Montori, Víctor M.

AU - Diette, Gregory B

AU - León-Velarde, Fabiola

AU - Rivera, María

AU - Wise, Robert A

AU - Sacksteder, Katherine

PY - 2015/8/6

Y1 - 2015/8/6

N2 - Background It is important to understand the local burden of non-communicable diseases including withincountry heterogeneity. The aim of this study was to characterise hypertension and type-2 diabetes profiles across different Peruvian geographical settings emphasising the assessment of modifiable risk factors. Methods Analysis of the CRONICAS Cohort Study baseline assessment was conducted. Cardiometabolic outcomes were blood pressure categories (hypertension, prehypertension, normal) and glucose metabolism disorder status (diabetes, prediabetes, normal). Exposures were study setting and six modifiable factors (smoking, alcohol drinking, leisure time and transportrelated physical activity levels, TV watching, fruit/ vegetables intake and obesity). Poisson regression models were used to report prevalence ratios (PR). Population attributable risks (PAR) were also estimated. Results Data from 3238 participants, 48.3% male, mean age 45.3 years, were analysed. Age-standardised (WHO population) prevalence of prehypertension and hypertension was 24% and 16%, whereas for prediabetes and type-2 diabetes it was 18% and 6%, respectively. Outcomes varied according to study setting (p <0.001). In multivariable model, hypertension was higher among daily smokers (PR 1.76), heavy alcohol drinkers (PR 1.61) and the obese (PR 2.06); whereas only obesity (PR 2.26) increased the prevalence of diabetes. PAR showed that obesity was an important determinant for hypertension (15.7%) and type-2 diabetes (23.9%). Conclusions There is an evident heterogeneity in the prevalence of and risk factors for hypertension and diabetes within Peru. Prehypertension and prediabetes are highly prevalent across settings. Our results emphasise the need of understanding the epidemiology of cardiometabolic conditions to appropriately implement interventions to tackle the burden of non-communicable diseases.

AB - Background It is important to understand the local burden of non-communicable diseases including withincountry heterogeneity. The aim of this study was to characterise hypertension and type-2 diabetes profiles across different Peruvian geographical settings emphasising the assessment of modifiable risk factors. Methods Analysis of the CRONICAS Cohort Study baseline assessment was conducted. Cardiometabolic outcomes were blood pressure categories (hypertension, prehypertension, normal) and glucose metabolism disorder status (diabetes, prediabetes, normal). Exposures were study setting and six modifiable factors (smoking, alcohol drinking, leisure time and transportrelated physical activity levels, TV watching, fruit/ vegetables intake and obesity). Poisson regression models were used to report prevalence ratios (PR). Population attributable risks (PAR) were also estimated. Results Data from 3238 participants, 48.3% male, mean age 45.3 years, were analysed. Age-standardised (WHO population) prevalence of prehypertension and hypertension was 24% and 16%, whereas for prediabetes and type-2 diabetes it was 18% and 6%, respectively. Outcomes varied according to study setting (p <0.001). In multivariable model, hypertension was higher among daily smokers (PR 1.76), heavy alcohol drinkers (PR 1.61) and the obese (PR 2.06); whereas only obesity (PR 2.26) increased the prevalence of diabetes. PAR showed that obesity was an important determinant for hypertension (15.7%) and type-2 diabetes (23.9%). Conclusions There is an evident heterogeneity in the prevalence of and risk factors for hypertension and diabetes within Peru. Prehypertension and prediabetes are highly prevalent across settings. Our results emphasise the need of understanding the epidemiology of cardiometabolic conditions to appropriately implement interventions to tackle the burden of non-communicable diseases.

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