Contribution of CYP11B2, REN and AGT genes in genetic predisposition to arterial hypertension associated with hyperaldosteronism

N. M. Chikhladze, K. F. Samedova, M. A. Sudomoina, Myo Thant, Zaw Min Htut, G. N. Litonova, A. V. Favorov, I. E. Chazova, O. O. Favorova

Research output: Contribution to journalArticle

Abstract

We carried out comparison of distribution of alleles and genotypes of polymorphic loci of renin-angiotensin-aldosterone system genes: CYP11B2 (C-344T), AGT (Thr174Met) and REN (C-5434T, C-5312T, and A BglI G) and their combinations in two groups of patients with low renin forms of arterial hypertension (AH). Group 1 included 59 patients with low renin hyperaldosteronism (HA) at the background of glomerular zone adenoma and hyperplasia of adrenal cortex. Group 2 included 28 patients with low renin hypertensive disease characterized by normal level of aldosterone. Complex analysis of carriership of allele and genotype combinations evidence for the difference in genetic nature of two forms of low renin AH. Participation of CYP11B2 and REN and possibly AGT genes in development of low renin AH was convincingly shown.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalKardiologiia
Volume48
Issue number1
StatePublished - Apr 22 2008
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Chikhladze, N. M., Samedova, K. F., Sudomoina, M. A., Thant, M., Htut, Z. M., Litonova, G. N., Favorov, A. V., Chazova, I. E., & Favorova, O. O. (2008). Contribution of CYP11B2, REN and AGT genes in genetic predisposition to arterial hypertension associated with hyperaldosteronism. Kardiologiia, 48(1), 37-42.